Comparison of Xylazine-Ketamine, Diazepam-Ketamine, and Diazepam-Thiopental Combinations in Goats Undergoing Rumentomy | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Articles in Press, Corrected Proof, Available Online from 23 January 2025 PDF (770.42 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2025.327075.2419 | ||||
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| Authors | ||||
Safaa Amin1; Abbas Sobair1; Awad Rizk  2; Mohamed Salem 3
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| 1Department of Surgery and Anesthesia, Faculty of Veterinary Medicine, Khartoum University, Khartoum, Sudan | ||||
| 2Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt | ||||
| 3Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, 35516 Mansoura, Egypt, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan. | ||||
| Abstract | ||||
| General anesthesia can be induced in goats using the same drugs commonly used in other species. These induction agents include thiopentone, propofol and ketamine, which can be administered with or without premedication. This study evaluated the effect of three injectable anesthetic protocols in Nubian goats undergoing rumentomy. This study was performed on 32 adult Nubian goats divided into 4 groups. Group 1(XK): Animals in this group were premedicated with xylazine HCl at a dose of 0.05 mg/kg BW and Ketamine HCl at a dose of 4mg/kg BW. Group2 (DK): Animals in this group were premedicated with diazepam at a dose of 0.5 mg/kg BW, and Ketamine HCl at a dose of 4mg/kg BW. Group 3(DT): Animals in this group were premedicated with diazepam at a dose of 0.5 mg/kg BW, and thiopentone sodium at a dose of 10 mg/kg BW. Group 4 (Control group): All animals in this group received all three aforementioned anesthetic protocols every 15 days intervals between two successive anesthetic treatments. Measurements of heart rate (HR), respiratory rate (RR), rectal temperature (RT), and length of the anesthetic phase, hemoglobin (Hb), packed cell volume (PCV), total protein (TP), blood glucose level, were made in controls, during surgery, and four weeks after the procedure at regular predetermined intervals. Both during the procedure and four weeks afterward, group XK experienced a significant (P < 0.05) reduction in HR and RR. The XK group experienced a substantial decrease (P < 0.05) in plasma TP during surgery, although the DK and DT groups also experienced a significant decrease in plasma TP four weeks after surgery. During the procedure, the DT group's plasma glucose level significantly increased. The DT group experienced a statistically significant increase in the length of the anesthetic phase. In conclusion, the combination of diazepam and thiopental generated safer, deeper and longer anesthesia during rumentomy in goats. | ||||
| Keywords | ||||
| Xylazine; Diazepam; Ketamine; Thiopental; Rumentomy; Goat | ||||
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