Association Between BAFF Gene Polymorphism And Clinical course of Newly Diagnosed Immune Thrombocytopenic Purpura In Children
Alhejny, E., hesham, M., mohamed, M., abdelmaguid, A. (2020). Association Between BAFF Gene Polymorphism And Clinical course of Newly Diagnosed Immune Thrombocytopenic Purpura In Children. EKB Journal Management System, 26(1), 165-173. doi: 10.21608/zumj.2019.7944.1043
Ebtihaj Almukhtar Alhejny; mervat Abdallah hesham; marwa Zakaria mohamed; amal fawzy abdelmaguid. "Association Between BAFF Gene Polymorphism And Clinical course of Newly Diagnosed Immune Thrombocytopenic Purpura In Children". EKB Journal Management System, 26, 1, 2020, 165-173. doi: 10.21608/zumj.2019.7944.1043
Alhejny, E., hesham, M., mohamed, M., abdelmaguid, A. (2020). 'Association Between BAFF Gene Polymorphism And Clinical course of Newly Diagnosed Immune Thrombocytopenic Purpura In Children', EKB Journal Management System, 26(1), pp. 165-173. doi: 10.21608/zumj.2019.7944.1043
Alhejny, E., hesham, M., mohamed, M., abdelmaguid, A. Association Between BAFF Gene Polymorphism And Clinical course of Newly Diagnosed Immune Thrombocytopenic Purpura In Children. EKB Journal Management System, 2020; 26(1): 165-173. doi: 10.21608/zumj.2019.7944.1043

Association Between BAFF Gene Polymorphism And Clinical course of Newly Diagnosed Immune Thrombocytopenic Purpura In Children

Zagazig University Medical Journal
Article 20, Volume 26, Issue 1, January and February 2020, Page 165-173  XML
Document Type: Original Article
DOI: 10.21608/zumj.2019.7944.1043
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Authors
Ebtihaj Almukhtar Alhejny email 1; mervat Abdallah heshamorcid 2; marwa Zakaria mohamedorcid 3; amal fawzy abdelmaguid4
1Pediatric department, faculty of Medicine, Zagzig University
2pediatric department, faculity of medicine, Zagazig university
3pediatric department, faculity of medicine, zagazig university
4biochemistry department, faculity of medicine, zagazig university
Abstract
Background : Primary immune thrombocytopenia is an autoimmune disorder characterized by autoantibody-mediated enhanced platelet destruction. BAFF gene polymorphisms increases BAFF expression and antibody production in ITP patients, which causes platelet destruction and megakaryopoiesis suppression
Objective: To study the frequency of BAFF gene polymorphisms in newly diagnosed ITP in children and their association with it's clinical features and course.
Methods: A case control study was conducted at Hematology Unit of pediatric department and Medical Biochemistry &Molecular Biology department at Zagazig University Hospital during a period from Nov. 2017 until Nov. 2018.The study Included 40 patients with newly diagnosed ITP (25 males and 15 females) and 20 age and sex-matched healthy children (11males and 9 females) as a control group. All children were subjected to a detailed medical history ,thorough clinical examination and Laboratory investigations including CBC , BM aspiration and B cell activating factor gene polymorphism (-871C/T) detection by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results: There was also a highly significant difference between ITP cases and control regarding distribution of SNP of BAFF gene where CT was founded in 55% of ITP cases versus 25% in control; also, CC was
founded in 75% of control versus 20% of cases. There was non-significant difference between different subtypes
of BAFF gene polymorphism regarding age, gender, initial bleeding events,CBC, type of treatment and outcome of ITP cases.
Conclusion: Significant association of BAFF gene polymorphism with newly diagnosed immune thrombocytopenic purpura in children may indicate its possible role in disease pathogenesis.
Keywords
BAFF; Gene polymorphism; Thrombocytopenic Purpura; children
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