Recent Advances in 2(3H)-Furanone Chemistry and Its Hydrazide Derivative: Synthesis and Reactions

El-Shanbaky, Hend Medhat; abdelhameed, rania Helmy; Mohamed, Mosaad Sayed; Fatahala, Samar Said

doi:10.21608/ejchem.2025.329442.10665

	Recent Advances in 2(3H)-Furanone Chemistry and Its Hydrazide Derivative: Synthesis and Reactions
Egyptian Journal of Chemistry
Volume 68, Issue 9, September 2025, Page 75-102 PDF (2.82 MB)
Document Type: Review Articles
DOI: 10.21608/ejchem.2025.329442.10665
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Authors
Hend Medhat El-Shanbaky ¹; rania Helmy abdelhameed ²; Mosaad Sayed Mohamed ¹; Samar Said Fatahala ³
¹Pharmaceutical organic chemistry department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
²Pharmaceutical Organic Chemistry Department, faculty of pharmacy, Helwan University
³Pharmaceutical Organic Chemistry Department, Faculty of pharmacy, Helwan University
Abstract
The 2(3H)-furanones and their hydrazide derivatives have a wide spectrum of biological activities, including anti-inflammatory, analgesic, antibacterial, antiviral, anticonvulsant, and anticancer properties. They are an important starting material for synthesis of numerous pyrrolone, pyridazinone, and imidazole derivatives. For these reasons, together with our interest in furanone chemistry, we decided to conduct a systematic study of contemporary synthesis and reactions from 2019 to 2023, with a special emphasis on the 3-arylidene-2(3H)-furanones. New furanones and hydrazides can be synthesized and utilized to obtain other heterocyclic compounds to identify their biological applications.
Keywords
Furanone; Hydrazide; Pyridazinone; Pyrrolone; Butanoic acid; γ-lactones


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