The effect of rotenone on the dopaminergic cells of the substantia nigra of the midbrain in the adult male albino rats
mahmod, M., A. GALHOM, R., NASR EL-DIN, ,., ALI, M., ABDEL-HAMID, S. (2017). The effect of rotenone on the dopaminergic cells of the substantia nigra of the midbrain in the adult male albino rats. EKB Journal Management System, 21(1), 247-257. doi: 10.21608/smj.2017.40762
MOHAMMED ABDEL-RAHMAN mahmod; RANIA A. GALHOM; , WAEL AMIN NASR EL-DIN; MONA H. MOHAMMED ALI; SAAD ABDEL-HAMID ABDEL-HAMID. "The effect of rotenone on the dopaminergic cells of the substantia nigra of the midbrain in the adult male albino rats". EKB Journal Management System, 21, 1, 2017, 247-257. doi: 10.21608/smj.2017.40762
mahmod, M., A. GALHOM, R., NASR EL-DIN, ,., ALI, M., ABDEL-HAMID, S. (2017). 'The effect of rotenone on the dopaminergic cells of the substantia nigra of the midbrain in the adult male albino rats', EKB Journal Management System, 21(1), pp. 247-257. doi: 10.21608/smj.2017.40762
mahmod, M., A. GALHOM, R., NASR EL-DIN, ,., ALI, M., ABDEL-HAMID, S. The effect of rotenone on the dopaminergic cells of the substantia nigra of the midbrain in the adult male albino rats. EKB Journal Management System, 2017; 21(1): 247-257. doi: 10.21608/smj.2017.40762

The effect of rotenone on the dopaminergic cells of the substantia nigra of the midbrain in the adult male albino rats

Sohag Medical Journal
Article 25, Volume 21, Issue 1, January 2017, Page 247-257  XML PDF (227.66 K)
Document Type: Original Article
DOI: 10.21608/smj.2017.40762
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Authors
MOHAMMED ABDEL-RAHMAN mahmod1; RANIA A. GALHOM2; , WAEL AMIN NASR EL-DIN3; MONA H. MOHAMMED ALI4; SAAD ABDEL-HAMID ABDEL-HAMID
1Department of Anatomy Faculty of Medicine, Sohag University
22Department of Anatomy & Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
32Department of Anatomy & Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt,
4Department of Anatomy, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia.
Abstract
Background aims.  Rotenone is a widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (SN) of midbrain producing Parkinsonism. The aim of this study is to study the effects of rotenone when injected subcutaneously on the dopaminergic cells of the substantia nigra of the midbrain.Methods. The effects of rotenone on the SN of midbrain and the were determinedhistopathologically, immunohistochemically, and by transmission electron microscopy. Results. Subcutaneous rotenone produced Parkinsonism through producing degeneration of the dopaminergic cells of SN of the midbrain. Conclusion. These results indicate that, rotenone has a neurodegenerative effect on the dopaminergic cells of the substantia nigra of the midbrain producing parkinsonism
Keywords
Dopaminergic neurons; Neurodegeneration; parkinsonism; Rotenone; Substantia nigra
Supplementary Files
References
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