Effect of the powder and alcoholic extract of leaves and peels of eggplant on cisplatin-induced toxicity in rats | ||||
| مجلة بØوث التربية النوعية | ||||
| Volume 2025, Issue 89, January 2025, Page 105-130 PDF (353.26 K) | ||||
| Document Type: مقالات علمیة Ù…Øکمة | ||||
| DOI: 10.21608/mbse.2025.337138.1554 | ||||
 View on SCiNiTO | ||||
| Author | ||||
سارة السيد 
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| مدرس مساعد كلية تربية نوعية جامعة المنصورة | ||||
| Abstract | ||||
| The purpose of this study was to investigate the impact of using the powder and the ethanolic extract of eggplant leaves and peels on liver and kidney functions and the antioxidant enzymes; superoxide dismutase (SOD) and glutathione peroxidase (GPX), in addition to an inflammatory marker; C-reactive protein (CRP). Phytochemical screening of the ethanolic extract of both leaves and peels was carried out. Also, their content of phenolic compounds, flavonoids, and anthocyanins was determined. In the animal experiment, 30 rats were divided into six groups (5 rats each); one group received a basal diet only (normal control). The remaining five groups were injected (IP) with cisplatin to induce hepato-nephrotoxicity; one remained on a basal diet and was considered a positive control. Two injured groups received the powder of leaves and peels, while the other two groups received the extracts of leaves and peels of eggplant. Rats were sacrificed after 28 days, and their blood was drawn for analysis. The phytochemical screening results indicated the presence of flavonoids, tannins, glycosides, saponins, and alkaloids. The results showed that the content of phenolic and flavonoid compounds was higher in the leaf than in the peel. On the contrary, the anthocyanin content of the peel was higher than that of the leaf. Regarding liver and kidney functions, the findings showed significant decreases in ALT, AST, and bilirubin and a substantial increase in serum total protein in the groups treated with the peel and leaf extracts. | ||||
| Keywords | ||||
| nephrotoxicity; hepatotoxicity; cisplatin | ||||
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