Synthesis, Characterization and Antibacterial Activity of Ciprofloxacin Loaded Nanoparticles
Abdelfattah, S., Ahmed Mousa, S., Hesham, H., Elshamsy, A., Saleh, D. (2024). Synthesis, Characterization and Antibacterial Activity of Ciprofloxacin Loaded Nanoparticles. EKB Journal Management System, 1(3), 56-69. doi: 10.21608/mermj.2025.349548.1021
shadwa Abdelfattah; Shadwa Abdelfattah Ahmed Mousa; Hamada Hesham; Ali Elshamsy; Doaa M Saleh. "Synthesis, Characterization and Antibacterial Activity of Ciprofloxacin Loaded Nanoparticles". EKB Journal Management System, 1, 3, 2024, 56-69. doi: 10.21608/mermj.2025.349548.1021
Abdelfattah, S., Ahmed Mousa, S., Hesham, H., Elshamsy, A., Saleh, D. (2024). 'Synthesis, Characterization and Antibacterial Activity of Ciprofloxacin Loaded Nanoparticles', EKB Journal Management System, 1(3), pp. 56-69. doi: 10.21608/mermj.2025.349548.1021
Abdelfattah, S., Ahmed Mousa, S., Hesham, H., Elshamsy, A., Saleh, D. Synthesis, Characterization and Antibacterial Activity of Ciprofloxacin Loaded Nanoparticles. EKB Journal Management System, 2024; 1(3): 56-69. doi: 10.21608/mermj.2025.349548.1021

Synthesis, Characterization and Antibacterial Activity of Ciprofloxacin Loaded Nanoparticles

Merit Medical Journal
Volume 1, Issue 3, July 2024, Page 56-69  XML PDF (699.3 K)
Document Type: Original Article
DOI: 10.21608/mermj.2025.349548.1021
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Authors
shadwa Abdelfattah email 1; Shadwa Abdelfattah Ahmed Mousa2; Hamada Hesham3; Ali Elshamsy4; Doaa M Saleh5
1Demonstrator in clinical pharmacy and pharmaceutical department, faculty of pharmacy, merit university, sohag Egypt
2Department of Pharmaceutics, Faculty of Pharmacy, Merit University Egypt (MUE), Sohag, Egypt
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.
43Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt.
5Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Merit University Egypt (MUE), Sohag, Egypt
Abstract
materials that can facilitate drug entrance into bacteria, enable penetration into biofilms, and exhibit synergism with their own functional characteristics. One method of slowing the development of antimicrobial resistance is to encapsulate antibacterial drugs in nanomaterial. By increasing the absorption of antimicrobial medications and thereby halting the development of resistant mutations, antibiotic-loaded nanoparticles may lessen antimicrobial resistance. Additionally, antibiotics at the nanoscale may be able to prevent efflux pumps. A New ciprofloxacin derivative 2 was synthesized and characterized. The newly synthesized compound 2 loaded nanoparticles evaluated as antibacterial agents against Staphylococcus aureus as Gram-positive bacteria and Escherichia coli and Pseudomonas aeruginosa as Gram-negative bacteria using ciprofloxacin as reference. The in vitro antibacterial screening revealed the higher potency of compound 2 loaded nanoparticles against Staphylococcus aureus with MIC value of 0.68 µg/mL than parent ciprofloxacin with MIC value of 3.24 µg/mL and lower activity against Escherichia coli and Pseudomonas aeruginosa (MIC range 0.85-1.17, µg/mL) compared to ciprofloxacin (MIC range 0.17-0.23, µg/mL). Molecular docking studies showed that compound 2 loaded nanoparticles exerts an additional significant binding towards topoisomerase II (gyrase) enzyme (PDB: 2XCT) active.
Keywords
Ciprofloxacin; Nanoparticles; Antibacterial; Molecular Docking
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