Study of hyperparathyroidism among patients with chronic kidney disease at sohag university hospital
hussein, A., Mahmoud, M., Zaki, N., Ali, A. (2017). Study of hyperparathyroidism among patients with chronic kidney disease at sohag university hospital. EKB Journal Management System, 21(3), 367-380. doi: 10.21608/smj.2017.41078
ahmed hussein; Mahmoud Mahmoud; Nayel Abd ELhameed Zaki; Ali Taha Ali. "Study of hyperparathyroidism among patients with chronic kidney disease at sohag university hospital". EKB Journal Management System, 21, 3, 2017, 367-380. doi: 10.21608/smj.2017.41078
hussein, A., Mahmoud, M., Zaki, N., Ali, A. (2017). 'Study of hyperparathyroidism among patients with chronic kidney disease at sohag university hospital', EKB Journal Management System, 21(3), pp. 367-380. doi: 10.21608/smj.2017.41078
hussein, A., Mahmoud, M., Zaki, N., Ali, A. Study of hyperparathyroidism among patients with chronic kidney disease at sohag university hospital. EKB Journal Management System, 2017; 21(3): 367-380. doi: 10.21608/smj.2017.41078

Study of hyperparathyroidism among patients with chronic kidney disease at sohag university hospital

Sohag Medical Journal
Article 43, Volume 21, Issue 3, October 2017, Page 367-380  XML PDF (132.71 K)
Document Type: Original Article
DOI: 10.21608/smj.2017.41078
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Authors
ahmed husseinorcid 1; Mahmoud Mahmoud1; Nayel Abd ELhameed Zaki2; Ali Taha Ali3
1Lecturer of internal medicine, faculty of medicine, Sohag university, sohag, egypt
2Department of Internal Medicine, Faculty of Medicine, Sohag University.
3Department of Internal medicine, Faculty of Medicine, Sohag University.
Abstract
Objectives:The aim of this study is to asses prevalence & clinical outcome of hyperparathyroidism among CKDpatients either on dialysis or not in Sohag University Hospital 1.To estimate serum intact parathormone(iPTH) and other biochemical parameters (calcium, inorganic phosphate, urea and creatinine)in CKDpatients2. To compare and find out correlation between serum intact parathormone and biochemicalparameters in the study group.
Patients &Methods: For the study of 5 stages of Chronic Kidney Disease(CKD) totally 100 patients in different stages inthe age group of 20-60 years were taken. Serum parathormone and other biochemical parameters were estimated using standard methods.Pelvi-abdominal ultrasonography,Plain x-ray,ECG & Echocardiography were also done.
Results:66 patients (66.00%) with PTH values above the normal range (hyperparathyroidism) (>72 pg/ml), with mean PTH = 481.92 ± 608.05,   and this is the prevalence rate of secondary hyperparathyroidism in the study population. The serum PTH levels were higher even in early stages of CKD and the higher values are directly related to the stage of CKD.  In the study, Serum phosphorus was found to be significantly positively correlated to PTH both in the total study population and in patients with hyperparathyroidism.The PTH was found to be significantly negatively correlated with serum total and ionized calcium of the patients, both in the total study population and in patients with hyperparathyroidism.Also the findings of this study as regard echocardiography in CKD patients;Left ventricular dysfunction was the commonest cardiovascular abnormality. LVH was the most common echocardiographic abnormality in CKD cases. Diastolic function was deranged in more number of patients as compared to systolic function in patients with CKD.
Conclusion: The estimation of serum PTH and other biochemical parameters can help to diagnose the secondary hyperparathyroidism in the early stage of CKD which inturn has advantage to manage the patients of CKD accordingly to prevent the future complications.
Supplementary Files
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