Factors Affecting Adherence of Patients withBronchial Asthma and Chronic ObstructivePulmonary Disease to Inhaled Therapy
Amin, E., Ata, K., Alkhayat, K., Khalil, A. (2019). Factors Affecting Adherence of Patients withBronchial Asthma and Chronic ObstructivePulmonary Disease to Inhaled Therapy. EKB Journal Management System, 23(Issue 1), 80-97. doi: 10.21608/smj.2019.41172
Esraa Amin; Kamal Ata; khaled Fawzy Alkhayat; Abdellah Khalil. "Factors Affecting Adherence of Patients withBronchial Asthma and Chronic ObstructivePulmonary Disease to Inhaled Therapy". EKB Journal Management System, 23, Issue 1, 2019, 80-97. doi: 10.21608/smj.2019.41172
Amin, E., Ata, K., Alkhayat, K., Khalil, A. (2019). 'Factors Affecting Adherence of Patients withBronchial Asthma and Chronic ObstructivePulmonary Disease to Inhaled Therapy', EKB Journal Management System, 23(Issue 1), pp. 80-97. doi: 10.21608/smj.2019.41172
Amin, E., Ata, K., Alkhayat, K., Khalil, A. Factors Affecting Adherence of Patients withBronchial Asthma and Chronic ObstructivePulmonary Disease to Inhaled Therapy. EKB Journal Management System, 2019; 23(Issue 1): 80-97. doi: 10.21608/smj.2019.41172

Factors Affecting Adherence of Patients withBronchial Asthma and Chronic ObstructivePulmonary Disease to Inhaled Therapy

Sohag Medical Journal
Article 18, Volume 23, Issue 1, January 2019, Page 80-97  XML PDF (398.63 K)
Document Type: Original Article
DOI: 10.21608/smj.2019.41172
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Authors
Esraa Amin1; Kamal Ata2; khaled Fawzy Alkhayat3; Abdellah Khalil4
1Department of Chest and Tuberculosis, Faculty of Medicine, Sohag University.
2Department of Chest Disease and Tuberculosis, Faculty of Medicine, Sohag University.
3Department of Chest Diseases, Faculty of Medicine, Sohag University.
4Department of Chest Disease and Tuberculosis, Faculty of Medicine, Sohag University.
Abstract
Background:adherence to medication is a growing issue and there aremany factors affecting adherence in bronchial asthma and COPD.
Objectives:This study was designed to determine the factors affectingadherence to inhalation therapy in asthma and chronic obstructivepulmonary disease.
Patients and Methods: The present study included 300 patients (164males and 136 females and 156 COPD and 144 asthma also 189 werealready on inhaler therapy and 111 were naive(no previous inhaler)whoattended Sohag university hospital (inpatient department and outpatientclinic of chest diseases)during the period from April 2016 to May 2017using morisky questionnaire to determine factors affecting adherence toinhaled therapy.
Results: 300 patients 164cases (54.67%) were males and 136 cases(45.73)were female, Good adherence to inhaled therapy was observed in 124 (35.3%) patients and both intermediate and good adherence was observed in 227 ( 64.6% ) patients. Most of the naive patients were poor adherent to inhaled therapy.There was no relationship between demographic data and adherence in asthmatic patients. However, there was significant relation between adherence and socioeconomic status and residence in COPD patients. Patients with bronchial asthma had better adherence to inhaled therapy than patients with COPD, However good adherence was frequently encountered in patients with COPD who had 2-4 emergency visits in the last year. Good adherence was observed frequently in patients who had ENT diseases as comorbidity, while poor adherence was observed frequently in patients who had cardiac disease. Good adherence was frequently encountered among asthmatic patients whoused inhaler twice daily, who used drugs its onset of action 5- 20 minutes, whoused aerolizer and turbohaler devices and who used budesonide and budesonide/formetrol. Good adherence was frequently encountered among patients with COPD who used inhaler twice daily, who used aerolizer and handihaler devices and who used formetrol and tiotropium
Conclusion: This study confirmed that many factors affect adherence toinhaled therapy,so the interventions to maintain adherence contain fivecategories should be joint together(patient related factors, condition related factors, drug related factors, healthcare system related and socioeconomic status)to improve adherence and thus quality of life.
Keywords
COPD; bronchial asthma; adherence; inhaled therapy
Supplementary Files
References
  1. Agh, Tamas, AndrasInotai, and Agnes Meszaros. "Factors associated with medication adherence in patients with chronic obstructive pulmonary disease." Respiration 82.4 (2011): 328-334.‏
  2. ANDERSON, Paula. Use of Respimat® soft Mist™ inhaler in COPD patients. International journal of chronic obstructive pulmonary disease, 2006, 1.3: 251.‏
  3. Axelsson M, Emilsson M, Brink E, et al. Personality, adherence, asthma control and health-related quality of life in young adult asthmatics. Respir Med 2009; 103: 1033–1040
  4. Braido, Fulvio. "Failure in asthma control: reasons and consequences." Scientifica 2013 (2013)
  5. BROWN, Marie T.; BUSSELL, Jennifer K. Medication adherence: WHO cares?. In: Mayo Clinic Proceedings. Elsevier, 2011. p. 304-314.‏
  6. Choi-Kwon S., Kwon S.U and Kim J.S. Compliance with risk factor modification: early-onset versus late-onset stroke patients, Eur. Neurol. 54 (2005) 204–211
  7. Dimatteo MR. The Psychology of Health, Illness and Medical Care: An Individual Perspective. Pacific Grove, Brooks/Cole, 1991
  8. E.Sabat´e, Adherence to Long-Term Therapies: Evidence for Action,World Health Organization, Geneva, Switzerland, 2003
  9. Friedman HS, Navaratnam P and McLaughlin J. Adherence and asthma control with mometasonefuroate versus fluticasone propionate in adolescents and young adults with mild asthma. J Asthma 2010; 47: 994–1000
  10. Global Initiative for Asthma (GINA),  2017
  11. Global Initiative for Chronic Obstructive Lung Disease: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. [Available from: http://www.goldcopd.it/gruppi_lavoro/2011/GOLDPOCKETGUIDE2010. pdf]
  12. HALPIN, David MG, et al. Effect of tiotropium on COPD exacerbations: a systematic review. Respiratory medicine, 2016, 114: 1-8.‏
  13. Hertz R.B, Unger A.N and Lustik M.B. Adherence with pharmacotherapy for type 2 diabetes: a retrospective cohort study of adults with employer-sponsored health insurance, Clin.Ther. 27 (2005) 1064–1073
  14. Hill,L.S;SLATER,A.L.A. Acomparison of the performance of the two modern multidose dry powder asthma inhalers.Respiratory medicine, 1998, 92.1: 105-110.
  15. Jin J, Sklar GE, Min Sen Oh V and Chuen Li S. Factors affecting therapeutic compliance: A review from the patient’s perspective. TherClin Risk Manag. 2008;4(1):269–286
  16. Latty P, Pinet M, Labat A, et al. Adherence to anti-inflammatory treatment for asthma in clinical practice in France. ClinTher. 2008;30 Spec No:1058–1068
  17. Lavsa S.M,  Holzworth A, and Ansani N.T “Selection of a validated scale for measuring medication adherence,” Journal of the American Pharmacists Association, vol. 51, no. 1, pp. 90–94, 2011.
  18. Morisky DE, Green LW and Levine DM. Concurrent and predictive
    validity of a self-reported measure of medication adherence. Med Care 1986; 24:67-74
  19. NizarRifaat , Elham Abdel-Hady  and Ali A. Hasan Egyptian Journal of Chest Diseases and Tuberculosis (2013) 62, 371–376
  20. Osterberg .L and  Blaschke .T “Adherence to medication,” The New England Journal of Medicine, vol. 353, no. 5, pp. 487–497, 2005
  21. Restrepo RD, Alvarez MT, Wittnebel LD, Sorenson H, Wettstein R, Vines DL, et al. Medication adherence issues in patients treated for COPD. Int J Chron Obstruct Pulmon Dis 2008; 3:371 e84
 

 

 

 

  1. Rotter JB: Social Learning and Clinical Psychology. New York: Prentice Hall;1979
  2. Sanduzzi et al. Multidisciplinary Respiratory Medicine 2014,9:60 Page 8 of 9http://www.mrmjournal.com/content/9/1/6.
  3. Senior .V, Marteau T.M and  Weinman .J, Self-reported adherence to cholesterol-lowering medication in patients with familial hyper cholesterolaemia: the role of illness perceptions. 2004 Nov;18(6):475-81.
  4. Spector SL et al. Compliance of patient with asthma with an experimental aerosolized medication: Implications for controlled clinical trials. Journal of Allergy and Clinical Immunology, 1986, 77:65–70.
  5. TOY, Edmond L., et al. Treatment of COPD: relationships between daily dosing frequency, adherence, resource use, and costs. Respiratory medicine, 2011, 105.3: 435-441.‏
  6. Vic S.A, Maxwell C.J and Hogan D.B. Measurement, correlates, and health outcomes of medication adherence among seniors, Ann.Pharmacother. 38 (2004) 303–312
  7.  World Health Organization: Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach; 2007.
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