Exploring the Correlation between MicroRNA-128 and MicroRNA-212 Expression and Cytokine Profiles in HPV-Induced Wart Patients: Implications for Immune Regulation and Targeted Therapeutic Approaches | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Volume 34, Issue 3, July 2025 | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2025.357026.1459 | ||||
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| Authors | ||||
Khaled A. Zidan  1; Mothana A. Khalil2; Asmaa I. Alajeel3
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| 1College of Pharmacy, University of Al Maarif, Al-Anbar, Iraq | ||||
| 2University of Anbar, College of Medicine, Department of Microbiology, Ramadi, Al-Anbar Governorate, Iraq | ||||
| 3University of Anbar, College of Medicine, Department of Internal Medicine, Ramadi, Al-Anbar Governorate | ||||
| Abstract | ||||
| Background Human papillomavirus infections have previously been linked to causing warts, and microRNAs (miRNAs) have been reported to play modes to modulate the immune response to these type infections. objective: This study examined the relationship between miR- 128/miR-212 expression and cytokine levels in HPV-related warts, exploring their role in immune responses and potential as therapeutic targets for HPV treatment. Methodology: miR-128 and miR-212 expression levels were measured by qRT-PCR in tissue samples, while levels of IFN-γ, TNF-α, and IL-10 cytokines were measured by ELISA in blood samples from 150 patients with HPV-induced warts. Results: Expression of miR-128 and miR-212 significantly correlated with cytokine profiles in HPV-induced warts. MiR-128 showed a strong positive correlation with IFN-γ, suggesting involvement in antiviral immunity. Weaker positive correlations existed between miR-128 and both TNF-α and IL-10. In contrast, miR-212 moderately negatively correlated with IFN-γ and had a slight positive correlation with TNF-α and IL-10. These results suggest an immunomodulatory role for miR-128 and indicate that the influence of miR-212 is less powerful. Conclusions: The correlation between expression of miR-128 and high IFN-γ revealed that miR-128 is a potential therapeutic target when using IFN-γ injection to treat HPV-induced warts and encourage more investigation of miR-128/miR-212 in the immune response of HPV infection and novel therapeutic strategies against HPV-induced warts. | ||||
| Keywords | ||||
| MicroRNA; HPV-induced Warts; Cytokines biomarkers; Immune Modulation; Therapeutic Targets | ||||
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