Synthesis of Novel 2,3-Disubstituted Quinazolin-4-(3H)-ones and Their Antibacterial Activity on the Ultra-structure of Some Pathogenic Microorganisms | ||||
| Egyptian Journal of Chemistry | ||||
| Article 9, Volume 60, Issue 6, December 2017, Page 1059-1066 PDF (459.15 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2017.1819.1152 | ||||
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| Authors | ||||
Mahmoud Refaee Akl1; Salwa El-Sayed   2; Khaled Saied3
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| 1Chemisty department, Faculty of Science, Ain Shams University, Cairo, Egypt | ||||
| 2Future Univ. | ||||
| 3Chemistry Department, Faculty of Pharmaceutical Science, Nahda University, Beni-Suef, Egypt | ||||
| Abstract | ||||
| A series of highly functionalized quinazolin-4-ones, with different substituents at position 3, have been concisely synthesized in good yields, via the reactions of 3-amino-6-bromo-2-undecy-lquinazoline-4(3H)-one with one carbon donor isothiocyanatobenzene, followed by α-chlorinated compounds and 1,2-dichloroethanone. Moreover, reactions of 6-bromo-2-undecyl-4H-benzo-[3,1]oxazin-4-one with different hydrazides were also examined, giving new 3-substituted quinazolin-4-one derivatives. Some of the new quinazolin-4-ones were screened against gram negative and positive bacteria and showed good to moderate antibacterial activity. Structures of all new synthesized compounds in this investigation were substantiated using spectroscopic IR, 1H-NMR and MS studies. | ||||
| Keywords | ||||
| Antibacterial; 3,1-benzoxazin-4-one; quinazolino-4-ones; hydrazides; 1,3-thiazolidin-4-ones | ||||
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