Effect of Proton Pump Inhibitors, Vitamin E and their co-administration on heart function and Oxidative Changes in Isoprenaline Induced Myocardial Infarction in Adult Male Albino Rats | ||||
| Benha Medical Journal | ||||
| Volume 37, Issue 1, May 2020 PDF (1.25 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2020.20487.1182 | ||||
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| Author | ||||
Abeer Ahmed Shoman 
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| department of physiology, faculty of medicine, Benha university | ||||
| Abstract | ||||
| Background: Myocardial infarction (MI) continues to be associated with high morbidity and mortality worldwide. Proton Pump inhibitors (PPIs) exhibit cardioprotective effects by several mechanisms. Vitamin E possess antioxidant properties. Aim: The present study has been designed to evaluate the combined cardioprotective effect of PPIs and vitamin E on biochemical and histopathological alteration in isoprenaline (ISO) induced myocardial infarction in rats. Methods: 30adult Wistar albino male rats divided into 5 groups as follow: Group I: Control fed a standard diet.Group II: rats were undergoing MI by ISO.Group III: Rats were pretreated pantoprazole (1.3 mg/kg, i.o) daily for 3 weeks. Group IV: Rats were pretreated with vitamin E (100 IU/kg i.o) daily for 3 weeks. Group V: Rats were given both pantoprazole (1.3 mg/kg, i.o) and vitamin E (100 IU/kg bw, i.p)daily. On 22thand 23thday, rats in groups (II-V) were injection i.pwith ISO (100mg/kg bw for successive two days). Results: ISO induced infarction in rats resultedin a significant elevation in ST segment height, T –wave voltage, Heart rate (HR), serum lactate dehydrogenase (LDH), malondialdehyde (MDA) and nitric oxide metabolites (NO), whereas it caused a significant (P < 0.05) decrease in systolic blood pressure(SBP) and serum superoxide dismutase (SOD) when compared with the control group. Moreover, interventions with PPIs supplementation and/or vitamin E significantly reversed the aforementioned parameters with better impact of their combination.Conclusion: PPIs combined with vitamin E exert potential protective effect against MI through lowering calcium overload and enhancement of antioxidant activity. | ||||
| Keywords | ||||
| Keywords: MI; PPIs; vitamin E; ISO and oxidative stress | ||||
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