Prevalence of Fluoroquinolone-Resistant Clinical Isolates of Escherichia Coli in Urinary Tract Infection
Yousef, L., Mohammed, A., Mohamed, A., Ali, D. (2018). Prevalence of Fluoroquinolone-Resistant Clinical Isolates of Escherichia Coli in Urinary Tract Infection. EKB Journal Management System, 22(1), 253-262. doi: 10.21608/smj.2018.41769
Laila Yousef; Ashraf k Mohammed; Ahmed M Mohamed; Doha M Ali. "Prevalence of Fluoroquinolone-Resistant Clinical Isolates of Escherichia Coli in Urinary Tract Infection". EKB Journal Management System, 22, 1, 2018, 253-262. doi: 10.21608/smj.2018.41769
Yousef, L., Mohammed, A., Mohamed, A., Ali, D. (2018). 'Prevalence of Fluoroquinolone-Resistant Clinical Isolates of Escherichia Coli in Urinary Tract Infection', EKB Journal Management System, 22(1), pp. 253-262. doi: 10.21608/smj.2018.41769
Yousef, L., Mohammed, A., Mohamed, A., Ali, D. Prevalence of Fluoroquinolone-Resistant Clinical Isolates of Escherichia Coli in Urinary Tract Infection. EKB Journal Management System, 2018; 22(1): 253-262. doi: 10.21608/smj.2018.41769

Prevalence of Fluoroquinolone-Resistant Clinical Isolates of Escherichia Coli in Urinary Tract Infection

Sohag Medical Journal
Article 40, Volume 22, Issue 1, January 2018, Page 253-262  XML PDF (133.83 K)
Document Type: Original Article
DOI: 10.21608/smj.2018.41769
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Authors
Laila Yousef1; Ashraf k Mohammed2; Ahmed M Mohamed2; Doha M Ali3
1Department of Clinical and Chemical pathology, Faculty of Medicine, Sohag University.
2Department of Clinical Pathology, Faculty of Medicine, Sohag University.
3Department of Clinical and chemical pathology, Sohag Faculty of Medicine, Sohag University.
Abstract
Introduction: The commonest bacterial agent involved in causation of UTIs is Escherichia coli. The emergence of FQ resistant uropathogenic E. coli is of great concern.
Aim of the work: to study resistance towards urinary E. coli with various generations of fluoroquinolones.
Patients & Methods:: our study was carried out in the Clinical Pathology Department, Sohag University Hospital during the period from June 2016 to May 2017. Our study included 140 participants. Isolates from the specimens were obtained and identified using; Gram staining, colony characteristics on different culture medias. VITEC 2 Compact 15 identification kits were be used to confirm the identification of the isolates
Results: E.coli was isolated from 100 patients (71%) of all patients complaining of UTI with positive urinary culture (study or case group). By studying prevalence of Antibiotic resistance of E.coli isolates reveals that fluoroquinolones show sensitivities of 42-46%. Also Nitrofurantoin has the highest sensitivity of 87%. This is followed by meropenem (67%).  Ampicillin shows sensitivity in only 6% of cases. Regarding drug sensitivity in out & inpatients, we find that all generations of fluoroquinolones show highly significant resistance ratios among inpatients compared to outpatients. Meropenem show resistance more in inpatients than outpatients, with significant difference, Ampicillin and Nitrofuratoin show non-significant difference.
Conclusion: our study show an increased fluoroquinolone resistance among uropathogenic E. coli isolates mainly in hospital admitted patients.
Keywords
Urinary tract infection (UTI); Escherichia coli and fluoroquinolone resistant E.coli
Supplementary Files
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