Value of High Sensitive CRP in Hyperglycemic Patients with Acute Coronary Syndrome | ||||
| Sohag Medical Journal | ||||
| Article 42, Volume 22, Issue 1, January 2018, Page 273-280 PDF (102.14 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/smj.2018.41790 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Alaa Ez El-Deen Said1; Omar Saad Mohammed2; Yasser Mohamed Kamal3; Adel Abdel Aziz El Sayed4 | ||||
| 1Department of Internal Medicine, Sohag university Hospital. | ||||
| 2Department Internal Medicine, Sohag university Hospital. | ||||
| 3Department of Internal medicine , Faculty of Medicine, Sohag University. | ||||
| 4Department Internal Medicine , Sohag university Hospital. | ||||
| Abstract | ||||
| BACKGROUND: Hyperglycemia on admission in patients with acute coronary syndromes is common, and it is a powerful predicator of increased risk of in hospital complications in patients with and without diabetes mellitus, high sensitivity c- reactive protein (hs- CRP) is a cardiovascular risk marker in patients with acute coronary syndrome. OBJECTIVES: 1. To determine the levels of high-sensitivity C-reactive protein (hs-CRP) in subjects of acute coronary syndrome with admission hyperglycemia whatever diabetic or not. 2. To determine the levels of high-sensitivity C-reactive protein (hs-CRP) in subjects of acute coronary syndrome without admission hyperglycemia. 3. To compare the results of the above two groups and assess the prognostic value of admission glucose and hs -CRP levels in hyperglycemic patients with acute coronary syndromes. DESIGN AND SETTING: Prospective study, at Sohag university hospital in Egypt. METHODS: We measured the blood glucose, hs -CRP, cardiac enzymes and HBAIC levels at admission in 100 consecutive patients with ACS. Glucose was categorized as ≤11.1mmol=200 mg/dl. hs -CRP negative 3 mg, HBAIC ≤ 6.5% or ≥ 6.5). RESULTS: In our study reveals a statistically significant relation between levels of admission glucose and left ventricular function (LV failure, pulmonary edema and cardiogenic shock) or arrhythmias in hyperglycemic patients with ACS (P< 0.0001). Also there is a significant relation between level of hs- CRP and LVF and type of myocardial infarction in-hospital complications. Also there is insignificant relation between HBAIC levels and left ventricular function in ACS at admission. CONCLUSION: We conclude that elevated admission glucose appears a more important in predicting in-hospital and short term complications particularly left ventricular failure and cardiogenic shock in patients with acute coronary syndromes. Also the increased levels of hs- CRP are a predictor for severity and extent of myocardial damage and left ventricular function especially in STEMI. The synergistic effect of associated both stress hyperglycaemia and hs- CRP is a strong predictor for poor ACS outcome. | ||||
| Keywords | ||||
| High-sensitivity C-reactive protein level; hyperglycemia; Inflammatory marker; Atherosclerosis; Acute Coronary Syndrome | ||||
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