Association between serum microrna-21 gene expression , carcinoemberyonic antigen and clinicopathological character for colorectal cancer | ||||
Zagazig University Medical Journal | ||||
Article 4, Volume 26, Issue 6, November 2020, Page 919-927 PDF (556.04 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zumj.2019.14149.1292 | ||||
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Authors | ||||
amal fathy ghareeb1; Randa Husseiny Mohamed2; Ahmed Raafat Abd el fattah3; sara fouad saadawy 4 | ||||
1medical biochemistry,medicine,zagazig | ||||
2medical biochemistry department/faculty of medicine/ zagzazig university /zagazig / sharkia | ||||
3General SurgeryDepartment, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
4medical biochemistry department /faculty of medicine/zagazig university/zagazig /sharkia | ||||
Abstract | ||||
Background and objetives: MicroRNAs (miRNAs) are small, noncoding RNAs that are involved in carcinogenesis through postranscriptional gene regulatory activity. The current study aimed to measure serum miR-21 expression levels and to evaluate their association with the outcome of colorectal cancer (CRC) and correlate it with carcinoemberyonic antigen level. Methods: Blood samples were collected from 48 CRC patients and 48 healthy controls. The expression levels of miR-21 were measured using a quantitative reverse transcription polymerase chain reaction (qRT-PCR).The results were analysed to assess the relationship between serum miR-21 levels and clinic pathological and prognostic factors. Results: A univariate analysis revealed that high expression levels of serum miR-21 were associated with higher local recurrence , TNM staging, PT staging ,venous invasion ,liver metastasis and recurrane (p=0.004),positively correlated with CEA. Conclusion: The expression level of serum miR-21 correlates with CEA, recurrence and some pathological parameters of CRC patients. Our results suggest that circulating serum miR-21 is a promising prognostic tumour marker, and they highlight the potential clinical utility of miR-21 expression as a diagnostic and prognostic marker for CRC prognosis. | ||||
Keywords | ||||
MicroRNA-21; CEA; colorectal cancer; correlation | ||||
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