A correlational study assessing the effect of gender on inflammatory markers and lipid profile in patients with type 2 diabetes | ||||
| Journal of Advanced Medical and Pharmaceutical Research | ||||
| Volume 6, Issue 1, March 2025, Page 69-78 PDF (841.06 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jampr.2025.356311.1087 | ||||
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| Authors | ||||
Rehab H. Werida   1; Eman M. Nada 2; Nashwa El-Gharbawy 3; Haidy A. Abass 4
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| 1Department of Clinical Pharmacy & Pharmacy Practice, Faculty of Pharmacy, Damanhur University, Damanhour, Egypt | ||||
| 2Ministry of Health and Population, Damanhour, Egypt. | ||||
| 3Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt. | ||||
| 4Department of Pharmaceutics, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt. | ||||
| Abstract | ||||
| Background and aim Type 2 diabetes is linked to a high incidence of cardiovascular complications. Inflammation poses a significant risk for diabetes complications. These complications differ between male and female patients, with gender influencing the prevalence of diabetes-related complications. The objective of this study is to assess the levels of lipid profile and circulating inflammatory biomarkers based on gender. Method We evaluated 23 male and 37 female patients with type 2 diabetes, measuring weight, height, and waist circumference and calculating body mass index (BMI). Serum levels of fasting blood glucose (FBG), 2-hour postprandial glucose (2h-PPG), glycated hemoglobin (HbA1c %), lipid profile, high sensitivity C-reactive protein (hs-CRP), fetuin-A, and sirtuin 1 were measured. Mann–Whitney U or t-test or chi-square test or was used for comparison between groups. Pearson’s correlation and logistic regression analysis were used to determine if two variables are related. Result Males had lower BMI and waist circumference than females (p <0.05). In females, serum levels of hs-CRP correlated with 2h-PPG (p < 0.05), triglycerides (p <0.01), and low-density lipoprotein cholesterol (LDL-C)(p< 0.01). In males, sirtuin 1 was negatively correlated with weight and BMI (p < 0.05). According to logistic regression, fetuin-A, sirtuin 1, and hs-CRP levels were not impacted by gender (p > 0.05). Conclusion Gender-specific impact in type 2 diabetes patients could be a predictor for diabetes complications. Women may be more susceptible to complications from diabetes than men for a variety of reasons, including weight and BMI. Gender did not affect inflammatory biomarkers. | ||||
| Keywords | ||||
| type 2 diabetes; gender; hs-CRP; fetuin-A; sirtuin 1 | ||||
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