Frequency of Cervical Intra-epithelial Neoplasia in Oral Contraceptive Pills Users in Zagazig University Hospitals
Attya, A., Ali, A., AbdelSalam, H., Abdelwahab, M. (2020). Frequency of Cervical Intra-epithelial Neoplasia in Oral Contraceptive Pills Users in Zagazig University Hospitals. EKB Journal Management System, 26(4), 590-597. doi: 10.21608/zumj.2019.13975.1275
Attya Mohamed Attya; Ali ElShabrawy Ali; Hoda Sibai AbdelSalam; Mai Mohamed Abdelwahab. "Frequency of Cervical Intra-epithelial Neoplasia in Oral Contraceptive Pills Users in Zagazig University Hospitals". EKB Journal Management System, 26, 4, 2020, 590-597. doi: 10.21608/zumj.2019.13975.1275
Attya, A., Ali, A., AbdelSalam, H., Abdelwahab, M. (2020). 'Frequency of Cervical Intra-epithelial Neoplasia in Oral Contraceptive Pills Users in Zagazig University Hospitals', EKB Journal Management System, 26(4), pp. 590-597. doi: 10.21608/zumj.2019.13975.1275
Attya, A., Ali, A., AbdelSalam, H., Abdelwahab, M. Frequency of Cervical Intra-epithelial Neoplasia in Oral Contraceptive Pills Users in Zagazig University Hospitals. EKB Journal Management System, 2020; 26(4): 590-597. doi: 10.21608/zumj.2019.13975.1275

Frequency of Cervical Intra-epithelial Neoplasia in Oral Contraceptive Pills Users in Zagazig University Hospitals

Zagazig University Medical Journal
Article 8, Volume 26, Issue 4, July 2020, Page 590-597  XML PDF (1.06 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2019.13975.1275
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Authors
Attya Mohamed Attya email 1; Ali ElShabrawy Ali1; Hoda Sibai AbdelSalam2; Mai Mohamed Abdelwahab3
1Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig university
2Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University
3Pathology Department, Faculty of Medicine, Zagazig university
Abstract
Background: Combined oral contraceptive pills (COCs) are widely used as contraceptive method. Some authors linked prolonged use of COCs to development of cervical intra-epithelial neoplasia (CIN). However, this link need more investigations to be proven.
The aim of the study: was to assess the association between the long term use of combined oral contraceptive pills and the development of cervical intra-epithelial neoplasia.
Patients & methods: This cross-sectional observational study was carried out in outpatient clinic of Obstetrics & Gynecology Department and Department of Pathology at Zagazig University Hospitals, Zagazig, Sharkia, Egypt, from December 2017 till January 2019. One hundred and thirty six cases were included. All women were currently using COCs or previously used it. Full history was taken from all women, PAP smear was taken, fixed on glass slide by alcohol 95%, then staining with Papanicolaou stain and finally interpretation of the results using Bethesda system 2014 was done.
Results: Abnormal PAP smear was correlated with the duration of COCs use, the longer the duration of COCs use, the higher the grade of abnormal PAP smear. Other factors that correlate positively with abnormal PAP smear in COC users were older age, longer marital life and higher parity (> 3). On the contrary, mode of delivery, history of cervical cauterization or complaint of vaginal discharge had no impact.
Conclusion: Positive association was noticed between the duration of COCs use and abnormal PAP smear and between its long term use and the higher grade of the abnormal PAP smear.
Keywords
Cervical intra-epithelial neoplasia; Pap smear; Combined oral contraceptive pills
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