. Correlation between Serum Estrogen Level and Endometrial Histology in Cases of Fibroid Uterus in Peri-menopausal Period | ||||
| Benha Medical Journal | ||||
| Article 1, Volume 42, Issue 5, May 2025, Page 1-9 PDF (569.56 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2025.426741 | ||||
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| Abstract | ||||
| Background: Uterine leiomyoma represents over 75% of the amiable tumours in ladies of conceptive age amass. Endometrium is a hormonally responsive tissue. The reaction of endometrium to incitement by endogenous or exogenous steroid hormones is unsurprising endogenous reaction is an impression of the hypothalamic–pituitary-ovarian pathway. Aim of this study: to assess serum level of E2 and study endometrial histological changes in instances of fibroid uterus. Patients and methods: This study included forty ladies have symptomatic fibroid uterus. history was taken, general examination, ultrasound examination, measuring serum estradiol and endometrial biopsy was taken by D&C or hysterectomy sent for histopathological examination. Results: endometrial thickness was ˃10mm in 69.2% of premenopausal and ˃5mm in 83%of postmenopausal. endometrial hyperplasia is the commonest glandular endometrial change represent (37.5%), complex hyperplasia without atypia 5%, simple hyperplasia with atypia 5% and proliferative endometrium 22.5%of all review bunch. in premenopausal patients hyperplasia with atypia related with the most elevated E2 level ( 252,6 pg) , complex hyperplasia without atypia with E2 level (221.6 ±6.22 SD), hyperplasia without atypia with E2 level (184.84 ± 12,11SD) and in postmenopausal patients hyperplasia with atypia with E2 level (245.3 pg), hyperplasia without atypia (145.68 ±33.53 SD) .Conclusion : there is correlation between serum oestrogen level , histopathological changes of endometrium and symptomatic fibroid uterus at perimenopausal age | ||||
| Keywords | ||||
| Estrogen; Endometrial histology; Fibroid; Peri-menopausal | ||||
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