PULMONARY FUNCTION CHANGES AFTER BRONCHOSCOPIC BIOLOGICAL LUNG VOLUME REDUCTION THERAPY USING AUTOULOGOUS BLOOD
Bakeer, M., Abd El-Gawad, T., Ali, R., El-Morsi, A., El-Badrawy, M., El-Sharawy, S. (2013). PULMONARY FUNCTION CHANGES AFTER BRONCHOSCOPIC BIOLOGICAL LUNG VOLUME REDUCTION THERAPY USING AUTOULOGOUS BLOOD. EKB Journal Management System, 19(5), 1-4. doi: 10.21608/zumj.2013.4313
Mostafa Bakeer; Taha Abd El-Gawad; Raed Ali; Ahmed El-Morsi; Mohammad El-Badrawy; Solafa El-Sharawy. "PULMONARY FUNCTION CHANGES AFTER BRONCHOSCOPIC BIOLOGICAL LUNG VOLUME REDUCTION THERAPY USING AUTOULOGOUS BLOOD". EKB Journal Management System, 19, 5, 2013, 1-4. doi: 10.21608/zumj.2013.4313
Bakeer, M., Abd El-Gawad, T., Ali, R., El-Morsi, A., El-Badrawy, M., El-Sharawy, S. (2013). 'PULMONARY FUNCTION CHANGES AFTER BRONCHOSCOPIC BIOLOGICAL LUNG VOLUME REDUCTION THERAPY USING AUTOULOGOUS BLOOD', EKB Journal Management System, 19(5), pp. 1-4. doi: 10.21608/zumj.2013.4313
Bakeer, M., Abd El-Gawad, T., Ali, R., El-Morsi, A., El-Badrawy, M., El-Sharawy, S. PULMONARY FUNCTION CHANGES AFTER BRONCHOSCOPIC BIOLOGICAL LUNG VOLUME REDUCTION THERAPY USING AUTOULOGOUS BLOOD. EKB Journal Management System, 2013; 19(5): 1-4. doi: 10.21608/zumj.2013.4313

PULMONARY FUNCTION CHANGES AFTER BRONCHOSCOPIC BIOLOGICAL LUNG VOLUME REDUCTION THERAPY USING AUTOULOGOUS BLOOD

Zagazig University Medical Journal
Article 41, Volume 19, Issue 5, September 2013, Page 1-4  XML PDF (165.68 K)
Document Type: Original Article
DOI: 10.21608/zumj.2013.4313
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Authors
Mostafa Bakeer1; Taha Abd El-Gawad1; Raed Ali1; Ahmed El-Morsi1; Mohammad El-Badrawy1; Solafa El-Sharawy2
1Chest Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura
Abstract
Background: Bronchoscopic lung volume reduction (BLVR) using biological agents is one of the new alternatives to lung volume reduction surgery.
Objectives: To evaluate the potential efficacy of bronchoscopic biological lung volume reduction using autologous blood injection in pulmonary emphysema patients.
Methods: 7 male patients were enrolled in the study. After determining the targeted emphysematous segment by high resolution computerized tomography (HRCT), 30 ml autologous blood was injected via balloon catheter over 10 to15 seconds into the targeted segment and left in position for 3-6 minutes allowing time for blood to coagulate. The bronchoscope was then repositioned at the following targeted segment. Changes in residual volume (RV), residual volume to total lung capacity ratio (RV/TLC), forced expiratory volume in one second (FEV1) and forced expiratory volume to forced vital capacity ratio (FEV1/FVC) were evaluated at 12-week post procedure as well as for complications.
Results: At 12-week post procedure there was statistically significant reduction in RV/TLC (p = 0.038). FEV1 significantly increased (p = 0.018). In addition, there was significant improvement in FEV1/FVC % (p = 0.003). All cases tolerated the procedure with no mortality. There was one case that developed pneumonia at the same side of intervention, and two cases developed mild haemoptysis (blood streaked sputum). There was no life threatening complications e.g (pneumothorax, pulmonary embolism, cardiac ischaemia or myocardial infarction) occurred htoughout the study.
Conclusion: Bronchoscopic lung volume reduction using autologous blood injection could be an effective, cheap and relatively safe method to treat advanced emphysema in comparison to other agents used in the clinical trials.
Keywords
emphysema; Bronchoscopy; Lung volume reduction
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