PROTECTIVE EFFECTS OF LOSARTAN AGAINST ETHANOL-INDUCED LIVER INJURY: A STUDY IN MALE WISTAR RATS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Volume 48, Issue 2, December 2025, Pages 1367-1377 PDF (654.17 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2025.363759.2459 | ||
| Authors | ||
| Mahdiyeh Hedayati -Moghadam1; Faezeh Mirzaee2; Fateme Seyedi3; Yousef Baghcheghi* 2, 4 | ||
| 1Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran | ||
| 2Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran | ||
| 3 Department of Anatomical Sciences, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran | ||
| 4Bio Environmental Health Hazards Research Center, Jiroft University of Medical Sciences, Jiroft, Iran | ||
| Abstract | ||
| Objectives: Chronic consumption of ethanol poses serious risks to liver health, resulting in oxidative stress and inflammation that can worsen hepatic dysfunction. This research explores the protective role of losartan, an angiotensin II receptor blocker (ARB), in countering ethanol-induced liver damage in male Wistar rats. Methods: A total of 28 male rats were categorized into four groups: control, ethanol, ethanol-losartan 1 mg/kg, and ethanol-losartan 3 mg/kg. Over a six-week period, the ethanol group was administered increasing doses of ethanol, while losartan was given intraperitoneally (IP) to the treatment groups. Results: Findings indicated that losartan significantly lowered markers of oxidative stress, as shown by reduced levels of malondialdehyde (MDA) and increased total thiol concentrations in liver tissues. Additionally, losartan treatment improved the activity of crucial antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT). Inflammatory markers, particularly interleukin-6 (IL-6), were significantly decreased in the losartan-treated groups compared to the ethanol-only group. Moreover, losartan enhanced liver function, evidenced by lower serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The higher dosage of losartan (3 mg/kg) exhibited more significant effects in reducing oxidative stress and restoring hepatic dysfunction induced by chronic administration. Conclusions: Losartan demonstrates considerable protective effects against liver injury induced by ethanol, attributed to its antioxidant and anti-inflammatory properties. These results indicate that losartan could be a promising therapeutic option for addressing alcohol-related liver damage, highlighting the need for further exploration of its mechanisms and potential clinical applications. | ||
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| Keywords | ||
| Losartan; Liver function; Oxidative Stress; Inflammation | ||
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