SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN
El Tarhouny, S., Zakaria, S., Hadhoud, K., Hanafi, M., Kamel, A., Al Nozha, O. (2014). SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN. EKB Journal Management System, 20(1), 1-7. doi: 10.21608/zumj.2014.4339
Shereen El Tarhouny; Soha Zakaria; Khaled Hadhoud; Manal Hanafi; Azza Kamel; Omar Al Nozha. "SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN". EKB Journal Management System, 20, 1, 2014, 1-7. doi: 10.21608/zumj.2014.4339
El Tarhouny, S., Zakaria, S., Hadhoud, K., Hanafi, M., Kamel, A., Al Nozha, O. (2014). 'SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN', EKB Journal Management System, 20(1), pp. 1-7. doi: 10.21608/zumj.2014.4339
El Tarhouny, S., Zakaria, S., Hadhoud, K., Hanafi, M., Kamel, A., Al Nozha, O. SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN. EKB Journal Management System, 2014; 20(1): 1-7. doi: 10.21608/zumj.2014.4339

SEX HORMONE BINDING GLOBULIN GENE POLYMORPHISM AND RISK OF TYPE2 DIABETES MELLITUS IN EGYPTIAN MEN

Zagazig University Medical Journal
Article 4, Volume 20, Issue 1, January 2014, Page 1-7  XML PDF (531.72 K)
Document Type: Original Article
DOI: 10.21608/zumj.2014.4339
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Authors
Shereen El Tarhouny1; Soha Zakaria2; Khaled Hadhoud3; Manal Hanafi4; Azza Kamel5; Omar Al Nozha6
1Medical Biochemistry Department, FOM, Zagazig University, Egypt & Taibah University, KSA
2Medical Biochemistry Department, FOM, Tanta University, Egypt & Taibah University, KSA
3Internal Medicine Department FOM, Zagazig University, Egypt
4Community Medicine Department FOM, Alexandria University, Egypt & Taibah University, KSA
5Medical Biochemistry Department, FOM, Menofia University, Egypt & Taibah University, KSA
6Medicine Department FOM, Taibah University, Al Madina, KSA
Abstract
Conditions of hypoandrogenism in men have been linked to insulin resistance, suggesting that alterations in normal sex steroid physiology could play a role in the pathogenesis of type 2 diabetes (T2DM). Sex hormone binding globulin gene polymorphisms may be the cause of sex steroid alteration The aim of this work to study effect of sex hormone binding globulin (SHBG) gene polymorphisms on type 2 diabetes mellitus risk through its impact on testosterone and estradiol level in Egyptian men. In 185 diabetic men and 120 matched healthy controls, two polymorphisms (rs6257 and rs6259) of the gene encoding sex hormone–binding globulin were genotyped and serum levels of sex hormone–binding globulin, testosterone and estradiol were measured by ELISA; Our results showed significant decrease in sex hormone binding globulins in type 2 diabetic patients compared with the control group. Carrier of variant allele of SHBG single nucleotide polymorphism (SNP) rs6259 had a higher level of SHBG in serum (p=0.000) While carrier of SHBG rs6257 SNP had a lower level of SHBG level in serum SHBG gene polymorphisms are associated with risk of type 2 diabetes in Egyptian men, through lowering circulating levels of sex hormone–binding globulin and consequently lowering testosterone and elevating estradiol level. SHBG rs6257 genotype may have a predictive value of developing type II diabetes mellitus
Keywords
Diabetes mellitus; SHBG; Gene polymorphism; testosterone; and estradiol
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