Effect of exercise on serum irisin level in normal and diabetic rats | ||||
| Sohag Medical Journal | ||||
| Article 31, Volume 23, Issue 1, January 2019, Page 195-201 PDF (449.04 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/smj.2019.43483 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hoda Mostafa Ahmed1; Amany Abdelrahman Abdelhamid  1; Zeinab Shaban Mohammed1; Nagwa Sayed Ahmad2
| ||||
| 1Department of Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||||
| 2Debartment of Biochemistry, Faculty of Medicine, Sohag University. | ||||
| Abstract | ||||
| Background:Exercise is an effective approach for controlling DM. the exact mechanism by which exercise can control DM is still unclear. In 2012, Boström and colleagues discovered that in muscle, exercise increases the expression of FNDC5 (Fibronectin type III domain-containing protein5),amembrane protein encoded by the FNDC5 gene. The FNDC5 protein is cleaved and secreted as a new hormone called irisin suggesting that some of beneficial effects of exercise could be mediated by this hormone. The aim of the study was to estimate effect of exercise on serum irisinand fasting blood glucose levels in normal and diabetic rats. Material and methods:120 adult male albino rats were categorized them into 4 groups. Diabetes mellitus was induced by intraperitoneal injection of freshly prepared alloxan monohydrate (160mg/kg) in a single dose in Group III and Group IV Physiological saline (0.9% Nacl) was injected intraperitoneally in Group Iand Group II. Fasting blood glucose was measured weekly and two months after swimming exercise serum levels of irisin and insulin were measured. Results:Exercise increased serum levels of irisin and insulin in both control and diabetic groups alsomeasurement of blood glucose level showed that exercise had decreasing effect on blood glucose in diabetic rats. Conclusion:Swimming exercise increases serum irisinlevel also improves fasting blood glucose and insulin sensitivityin diabetic rats. | ||||
|
Supplementary Files
|
||||
| References | ||||
|
1)Angelis K De, Irigoyen MC, Morris M (2009): Diabetes and cardiovascular autonomic dysfunction. Auton.Neurosci. 145, 3–10.
2)Dunstan D. (2011): Diabetes: exercise and T2DM-move muscles more often! Nat. Rev. Endocrinol. 7, 189–190
3)Ravussin E and Galgani JE (2011): The implicationof brown adipose tissue for humans. Annu. Rev. Nutr.31, 33-47.
4)Zhou Z, Yon Toh S, Chen Z, Guo K, Ng C P, Ponniah S, Lin S C, Hong W, Li (2003):.Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35, 456.
5)Boström P, Wu J , Jedrychowski M P, Korde A, Ye L, Lo J C, Rasbach K A, Boström E A, Choi J H, Long J Z, Kajimura S, Zingaretti MC , Vind BF, Tu H, Cinti S, Højlund K, Gygi S P, Spiegelman BM (2012): A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481, 463–468
6) Sanchis-Gomar F, Perez-Quilis C (2014): The p38-PGC-1alpha-irisin-betatrophin axis: exploring new pathways in insulin resistance. Adipocyte . 3(1): 67–68.
7)Szkudelski T (2001):The mechanism of alloxan and streptozotocin action in β cells of rat pancreas. Physiology Research Journal, 50:536-546.
8) Lackland DT, Voeks JH (2014): Metabolic syndrome and hypertension: regular exercise as part of lifestyle management. CurrHypertens Rep 16(11): 492.
9) Yang M , Peihong Chen, Hua Jin, XinmiaoXie, Ting Gao, Lili Yang , XuemeiYuEmail author (2014):Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus correlation with pancreatic ß-cell function. Diabetol.Metab.Syndr. 6, 133 .
10) Liu T Y, Shi CX1, Gao R1, Sun HJ1, Xiong XQ1, Ding L1, Chen Q2, Li YH2, Wang JJ1, Kang YM3, Zhu GQ4 (2015):Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes. Clin. Sci. (Lond.) 129, 839–850 .
11) Huh J Y , Mougios V, Kabasakalis A, Fatouros I, Siopi A, Douroudos II, Filippaios A, Panagiotou G, Park KH, Mantzoros CS(2014):Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. J. Clin. Endocrinol.Metab. 99, E2154–E2161
12) Kanaley JA, Timothy D. Heden, Ying Liu,1 Adam T. Whaley-Connell, AnandChockalingam, Kevin C, Dellsperger, Timothy J. Fairchild (2014):Short term aerobic exercise training increases postprandial pancreatic polypeptide but not peptide YY concentrations in obese individuals. Int J Obes (Lond), 38(2): 266–271. | ||||
|
Statistics Article View: 319 PDF Download: 289 |
||||
