GC-MS AND LC-MS ANALYSIS UNVEIL THE MULTIFACETED BIOACTIVITY OF EREMINA DESERTORUM SNAIL MUCUS: ANTIMICROBIAL, ANTIOXIDANT, WOUND REGENERATION, AND ANTICANCER EFFICACY AUGMENTED BY MOLECULAR DOCKING INSIGHTS
Ali, S., Ibrahim, A., Atta, S., Hamada, M., Gamil, I., El-Sayed, H., Morad, M. (2025). GC-MS AND LC-MS ANALYSIS UNVEIL THE MULTIFACETED BIOACTIVITY OF EREMINA DESERTORUM SNAIL MUCUS: ANTIMICROBIAL, ANTIOXIDANT, WOUND REGENERATION, AND ANTICANCER EFFICACY AUGMENTED BY MOLECULAR DOCKING INSIGHTS. EKB Journal Management System, 48(2), 1151-1171. doi: 10.21608/bfsa.2025.367074.2471
Sheriene E. Ali; Amina M. Ibrahim; Shimaa Attia Atta; Marwa A. Hamada; Irene Sameh Gamil; Heba El-Sayed; Mostafa Y. Morad. "GC-MS AND LC-MS ANALYSIS UNVEIL THE MULTIFACETED BIOACTIVITY OF EREMINA DESERTORUM SNAIL MUCUS: ANTIMICROBIAL, ANTIOXIDANT, WOUND REGENERATION, AND ANTICANCER EFFICACY AUGMENTED BY MOLECULAR DOCKING INSIGHTS". EKB Journal Management System, 48, 2, 2025, 1151-1171. doi: 10.21608/bfsa.2025.367074.2471
Ali, S., Ibrahim, A., Atta, S., Hamada, M., Gamil, I., El-Sayed, H., Morad, M. (2025). 'GC-MS AND LC-MS ANALYSIS UNVEIL THE MULTIFACETED BIOACTIVITY OF EREMINA DESERTORUM SNAIL MUCUS: ANTIMICROBIAL, ANTIOXIDANT, WOUND REGENERATION, AND ANTICANCER EFFICACY AUGMENTED BY MOLECULAR DOCKING INSIGHTS', EKB Journal Management System, 48(2), pp. 1151-1171. doi: 10.21608/bfsa.2025.367074.2471
Ali, S., Ibrahim, A., Atta, S., Hamada, M., Gamil, I., El-Sayed, H., Morad, M. GC-MS AND LC-MS ANALYSIS UNVEIL THE MULTIFACETED BIOACTIVITY OF EREMINA DESERTORUM SNAIL MUCUS: ANTIMICROBIAL, ANTIOXIDANT, WOUND REGENERATION, AND ANTICANCER EFFICACY AUGMENTED BY MOLECULAR DOCKING INSIGHTS. EKB Journal Management System, 2025; 48(2): 1151-1171. doi: 10.21608/bfsa.2025.367074.2471

GC-MS AND LC-MS ANALYSIS UNVEIL THE MULTIFACETED BIOACTIVITY OF EREMINA DESERTORUM SNAIL MUCUS: ANTIMICROBIAL, ANTIOXIDANT, WOUND REGENERATION, AND ANTICANCER EFFICACY AUGMENTED BY MOLECULAR DOCKING INSIGHTS

Bulletin of Pharmaceutical Sciences Assiut University
Volume 48, Issue 2, December 2025, Pages 1151-1171    PDF (1.29 M)
Document Type: Original Article
DOI: 10.21608/bfsa.2025.367074.2471
Authors
Sheriene E. Ali* 1; Amina M. Ibrahim2; Shimaa Attia Atta3; Marwa A. Hamada4; Irene Sameh Gamil5; Heba El-Sayed4; Mostafa Y. Morad5
1Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt.
2Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt
3Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt
4Botany and Microbiology Department, Faculty of Science, Helwan University, Cairo, Egypt
5Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt
Abstract
This study investigated the biological properties of Eobania desertorum snail mucus, focusing on its antimicrobial, antioxidant, wound healing, and antitumor activities. Gas chromatography-mass spectrometry (GC-MS) analysis identified key compounds, including triphenylmethane, palmitic acid, and pentadecanoic acid. In contrast, liquid chromatography-mass spectrometry (LC/MS) detected metabolites such as betaine, thiamine, leucine, and tryptophan. The mucus exhibited low antibacterial but moderate antifungal activity. It showed strong antioxidant potential, effectively scavenging DPPH free radicals (IC50 = 8.88 µg/mL). Wound healing was significantly enhanced in treated mice and in vitro scratch assays. The mucus also displayed potent anticancer effects, significantly inhibiting HepG-2 liver cancer (IC50 = 3.6 mg/mL) and CaCo-2 colorectal cancer (IC50 = 0.2 µg/mL) cell proliferation. Molecular docking revealed strong interactions of hexadecanoic acid with cancer and microbial receptors. These important findings suggest that E. desertorum mucus is a promising natural resource for biomedical applications, including wound healing, antioxidants, and innovative cancer therapy.
 

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Keywords
Eremina desertorum; antimicrobial; wound healing; Caco-2cell lines; HepG-2 cell line
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