Evaluation of three Glomerular Filtration Rate (GFR) Equations Discriminates Stages of Chronic Kidney Disease (CKD) in Sudanese Patients
Ginawi, T., Bakhit, S., Kausar, M. (2019). Evaluation of three Glomerular Filtration Rate (GFR) Equations Discriminates Stages of Chronic Kidney Disease (CKD) in Sudanese Patients. EKB Journal Management System, 11(2), 111-122. doi: 10.21608/eajbsc.2019.43564
Tarig A.N Ginawi; Siham M.A. Bakhit; Mohd Adnan Kausar. "Evaluation of three Glomerular Filtration Rate (GFR) Equations Discriminates Stages of Chronic Kidney Disease (CKD) in Sudanese Patients". EKB Journal Management System, 11, 2, 2019, 111-122. doi: 10.21608/eajbsc.2019.43564
Ginawi, T., Bakhit, S., Kausar, M. (2019). 'Evaluation of three Glomerular Filtration Rate (GFR) Equations Discriminates Stages of Chronic Kidney Disease (CKD) in Sudanese Patients', EKB Journal Management System, 11(2), pp. 111-122. doi: 10.21608/eajbsc.2019.43564
Ginawi, T., Bakhit, S., Kausar, M. Evaluation of three Glomerular Filtration Rate (GFR) Equations Discriminates Stages of Chronic Kidney Disease (CKD) in Sudanese Patients. EKB Journal Management System, 2019; 11(2): 111-122. doi: 10.21608/eajbsc.2019.43564

Evaluation of three Glomerular Filtration Rate (GFR) Equations Discriminates Stages of Chronic Kidney Disease (CKD) in Sudanese Patients

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Article 10, Volume 11, Issue 2, March 2019, Page 111-122  XML PDF (1.27 MB)
Document Type: Original Article
DOI: 10.21608/eajbsc.2019.43564
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Authors
Tarig A.N Ginawi1; Siham M.A. Bakhit2; Mohd Adnan Kausar3
11-Department of Biochemistry, College of Medicine, University of Hail, Kingdom of Saudi Arabia 2-Department of Biochemistry, College of Medicine, Alzaiem Alazhari University, Khartoum Bahri, Sudan
2Department of Biochemistry, College of Medicine, Alzaiem Alazhari University, Khartoum Bahri, Sudan
3Department of Biochemistry, College of Medicine, University of Hail, Kingdom of Saudi Arabia
Abstract
Background: Chronic kidney disease (CKD), represent a diagnostic challenge. CKD is an asymptomatic disease, tests for screening and early diagnoses are critical in nephrology.
Objectives: To assess the potential role of a three glomerular filtration rate (GFR) calculation equations in discriminating between stages of chronic kidney disease (CKD) in Sudanese patients.
Methods: The study was carried out at Khartoum State, Sudan from July 2017 to August 2017. Three hundred and seventy-five (375) CKD patients aged 18–90, their GFR have been estimated by three equations as follows: combined creatinine (cr) and cystatin C (cysC) equation (GFRcr-cysC), Modification of Diet in Renal Disease (MDRD) equation (GFRcr) and CystatinC-based equation (GFRcysC). The discriminating ability between stages was tested by ROC analysis.
Results: The area under the receiver operating (AUC) curve values of the discriminated stages was tested by ROC analysis as the follows: between stage 1 and 2 were: GFRcr-cysC; 0.98 (p > 0.001), GFRcr; 0.77 (p < 0.001) and GFRcysC; 0.82 (p < 0.01). Between stage 2 and 3 were: GFRcr-cysC; 0.98 (p > 0. 001), GFR cr; 0.82 (p < 0.001) and GFRcysC; 0.89 (p < 0. 001). Between stage 3 and 4 were: GFRcr-cysC; 0.96 (p > 0. 001), GFRcr; 0.92 (p < 0.001) and GFRcysC; 0.67 (p < 0. 001). Between stage 4 and 5 were: GFRcr-cys; 0.99 (p > 0. 001), GFRcr; 0.95 (p < 0.001) and GFRcysC; 0.65 (p < 0. 001). GFRcr-cysC had the highest AUC of all.
Conclusion: Taking together, the study demonstrated that GFRcr-cysC equation is a valuable marker for early detection of CKD
Keywords
Plasma cystatin C; Plasma creatinine; Glomerular Filtration Rate; CKD; ROC analysis
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