ASSESSMENT OF CYTOTOXIC AND ANTICANCER ACTIVITY OF Zygophyllum album AND Suaeda palastina EXTRACTS ON HUMAN LIVER CANCER CELL LINES
El-Attar, M., Awad, A., Abdel-Tawab, F., Kamel, H., Ahmad, S., Hassan, A. (2019). ASSESSMENT OF CYTOTOXIC AND ANTICANCER ACTIVITY OF Zygophyllum album AND Suaeda palastina EXTRACTS ON HUMAN LIVER CANCER CELL LINES. EKB Journal Management System, 27(1), 539-544. doi: 10.21608/ajs.2019.43663
Marwa M. El-Attar; A. A. Awad; F. M. Abdel-Tawab; H. A. Kamel; S. Ahmad Ahmad; Amal I. Hassan. "ASSESSMENT OF CYTOTOXIC AND ANTICANCER ACTIVITY OF Zygophyllum album AND Suaeda palastina EXTRACTS ON HUMAN LIVER CANCER CELL LINES". EKB Journal Management System, 27, 1, 2019, 539-544. doi: 10.21608/ajs.2019.43663
El-Attar, M., Awad, A., Abdel-Tawab, F., Kamel, H., Ahmad, S., Hassan, A. (2019). 'ASSESSMENT OF CYTOTOXIC AND ANTICANCER ACTIVITY OF Zygophyllum album AND Suaeda palastina EXTRACTS ON HUMAN LIVER CANCER CELL LINES', EKB Journal Management System, 27(1), pp. 539-544. doi: 10.21608/ajs.2019.43663
El-Attar, M., Awad, A., Abdel-Tawab, F., Kamel, H., Ahmad, S., Hassan, A. ASSESSMENT OF CYTOTOXIC AND ANTICANCER ACTIVITY OF Zygophyllum album AND Suaeda palastina EXTRACTS ON HUMAN LIVER CANCER CELL LINES. EKB Journal Management System, 2019; 27(1): 539-544. doi: 10.21608/ajs.2019.43663

ASSESSMENT OF CYTOTOXIC AND ANTICANCER ACTIVITY OF Zygophyllum album AND Suaeda palastina EXTRACTS ON HUMAN LIVER CANCER CELL LINES

Arab Universities Journal of Agricultural Sciences
Article 50, Volume 27, Issue 1, March 2019, Page 539-544  XML PDF (715.78 K)
Document Type: Original Article
DOI: 10.21608/ajs.2019.43663
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Authors
Marwa M. El-Attar1; A. A. Awad2; F. M. Abdel-Tawab2; H. A. Kamel1; S. Ahmad Ahmad3; Amal I. Hassan1
1Radioisotopes Dept., Atomic Energy Authority, Egypt
2Genetics Dept., Fac. of Agric., Ain Shams Univ., P.O. Box 68, Hadayek Shubra 11241,Cairo, Egypt
3Cell Biology Dept., National Research Centre, Dokki, Giza, Egypt
Abstract
In this study, anticancer activity of Zygophyllum album and Suaeda palastina extracts was evaluated. Dichloromethane, methanol and hot water were used as solvents for extraction. Results indicated that the highest half-maximal inhibitory concentration (IC50) on human lung carcinoma (A549) cell lines was achieved by dichloromethane extracts of Z. album and S. palastina (70.48 μg/ml and 34.82 μg/ml respectively) compared to methanolic and hot water extracts. Furthermore, dichloromethane extracts of both plants had antiproliferative effect and highly cytotoxicity on human cancer cells. IC50 of Z. album was 27.74 μg/ml in the human hepatocellular carcinoma (HepG2), while IC50 of S. palaestina was 30.76 μg/ml with no cytotoxic activity on normal cell lines. In conclusion, these results suggest that Z. album and S. palaestina could be a good candidate species as a natural source of anticancer agents.
Keywords
medicinal plants; Cytotoxic activity; Zygophyllum album; Suaeda palaestina; anticancer agent; MTT assay; human liver cancer cell line
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