Influence of Various Intermittent Fasting Regimens on Obese Diabetic Female Rats | ||||
| مجلة الاقتصاد المنزلي | ||||
| Volume 41, Issue 1, March 2025, Page 181-204 PDF (656.58 K) | ||||
| Document Type: المقالة الأصلية | ||||
| DOI: 10.21608/jhe.2025.436690 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Amira Mostafa Kamel1; Hany Gaber EL-Masry1; Shaimaa H. Negm2 | ||||
| 1Nutrition and Food Science Department, Faculty of Home Economics, Helwan University | ||||
| 2Home Economics Dept., Specific Education Faculty, Port Said University, Egypt | ||||
| Abstract | ||||
| This study aims to evaluate the effects of various intermittent fasting (IF) regimens, i.e., time-restricted fasting (TRF), alternate day fasting (ADF), and periodic fasting (PF) on obese diabetic rats. Forty adult male albino rats weighing 150 ± 10 g used in this study. After the first week of adaptation rats were randomly divided into 5 equal groups (n=8). Group 1 was fed on ba basal diet (as a negative control group) (NC); Group 2 was fed on a high-fat diet (obese diabetic only) (as a positive control group), while the other three groups were fed on (HFD + IF regimens, i.e. (TRF, ADF, and PF), respectively. Type 2 diabetes was induced in all groups, except for the NC group, by intramuscular administration of streptozotocin (55 mg/kg). The IF interventions were administered for 4 weeks. Results revealed that the rats in all the treated groups, exhibited significant weight loss in the TRF, ADF, and PF groups, respectively, as compared to positive groups (obese diabetic group). The blood glucose levels decreased to varying degrees, with the PF group showing the most significant decrease (28.03%), followed by the ADF (15.79%) and TRF (32.22%) groups. The plasma insulin levels and insulin tolerance, leptin concentration, liver and kidney functions in addition to lipid profile were improved. In addition, antioxidants enzymes (CAT, SOD and GPX) were significantly (P<0.05) increased while, significantly reduced MDA as compared to the positive control group. The study findings indicate that while the IF protocols led to body weight loss, they exhibited varying effects on glycemic control and other metabolic parameters. | ||||
| Keywords | ||||
| Intermittent fasting; Calorie restriction; Restricted eating; Alternate day fasting; Periodic fasting; Glycemic control; Body weight; obesity; Diabetes | ||||
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