GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE
Said, G., Hussein, Y., El-Sayed, H., Askar, M. (2014). GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE. EKB Journal Management System, 20(2), 1-8. doi: 10.21608/zumj.2014.4371
Gina Said; Youssri Hussein; Hoda El-Sayed; Mervat Askar. "GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE". EKB Journal Management System, 20, 2, 2014, 1-8. doi: 10.21608/zumj.2014.4371
Said, G., Hussein, Y., El-Sayed, H., Askar, M. (2014). 'GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE', EKB Journal Management System, 20(2), pp. 1-8. doi: 10.21608/zumj.2014.4371
Said, G., Hussein, Y., El-Sayed, H., Askar, M. GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE. EKB Journal Management System, 2014; 20(2): 1-8. doi: 10.21608/zumj.2014.4371

GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE

Zagazig University Medical Journal
Article 17, Volume 20, Issue 2, March 2014, Page 1-8  XML PDF (651.7 K)
Document Type: Original Article
DOI: 10.21608/zumj.2014.4371
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Authors
Gina Said1; Youssri Hussein2; Hoda El-Sayed3; Mervat Askar3
1Biochemistry Department, Faculty of Pharmacy, Zagazig University, Egypt, Biochemistry Department, Faculty of Pharmacy, MSA University, Egypt
2Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Egypt
3Biochemistry Department, Faculty of Pharmacy, Zagazig University, Egypt
Abstract
Objective: The imbalance between pro-inflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of transforming growth factor beta-1 (TGF- β1) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the gene in susceptibility and severity of RA and osteoporosis.
Methods: Eighty-six RA patients and eighty-four control were enrolled in the study.
Genotyping of TGF- β1 T/C869 and TGF- β1 G/A800 was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).
Results: Subjects carrying T allele of TGF- β1 T/C869 genotype were significantly more likely to have osteoporosis than subjects carrying C allele (OR:6.95, 95% CI: 2.7-15.7, P: 0.001).Also, Subjects with A allele of TGF- β1 G/A800 genotype were significantly more likely to have osteoporosis (OR: 1.13, 95% CI: 1.05-1.2, P: 0.001).
Conclusion: T/C869 genotype and G/A800 genotype of TGF-β1 gene affecting on severity of RA and have the ability to develop the risk to osteoporosis in patients carrying T allele and A allele of T/C869 and G/A800 gene polymorphism respectively
Keywords
Transforming growth factor beta-1 (TGF-β1); Rheumatoid Arthritis; Polymorphism; Osteoporosis
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