Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital
Soliman, N., Gobran, F., Attia, F., Elessawy, N. (2016). Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital. EKB Journal Management System, 19(1), 60-67. doi: 10.21608/scumj.2016.43948
Nashaat M Soliman; Fikry Gobran; Fadia M Attia; Nashwa R Elessawy. "Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital". EKB Journal Management System, 19, 1, 2016, 60-67. doi: 10.21608/scumj.2016.43948
Soliman, N., Gobran, F., Attia, F., Elessawy, N. (2016). 'Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital', EKB Journal Management System, 19(1), pp. 60-67. doi: 10.21608/scumj.2016.43948
Soliman, N., Gobran, F., Attia, F., Elessawy, N. Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital. EKB Journal Management System, 2016; 19(1): 60-67. doi: 10.21608/scumj.2016.43948

Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital

Suez Canal University Medical Journal
Article 7, Volume 19, Issue 1, March 2016, Page 60-67  XML PDF (624.94 K)
Document Type: Original Article
DOI: 10.21608/scumj.2016.43948
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Authors
Nashaat M Soliman email 1; Fikry Gobran2; Fadia M Attia2; Nashwa R Elessawy2
1Departments of Infectious and Endemic Diseases Faculty of Medicine, Suez Canal University, Egypt
2Departments of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Chronic hepatitis C (CHC) continues to be a public health problem in Egypt with data suggesting that its incidence may be increasing. Hepatitis C virus (HCV) infection has been associated with a variety of extra-hepatic manifestations, including autoimmune disorders. Aim: To assess the prevalence of autoimmune neutropenia (AIN) in chronic liver disease (CLD) patients with HCV. Patients and Methods: A case-control design was used to fulfill the study objective. It was conducted on 60 subjects, divided into 2 groups: group 1 (30 HCV-infected patients with low total leucocytic count [TLC] as a study group) and group 2 (30 HCV-infected patients with normal TLC as a control group). AIN was evaluated by granulocyte immuno-fluorescence test (GIFT) to detect auto-antibodies against neutrophils in HCV-infected patients presented with neutropenia. Results: The mean age of the first group was 49.9±11.6 years, while the mean age of the second group was 52.7±11.3 years. Male gender was found in 53.3% of the low TLC group compared to 63.3% in normal TLC group; Positive GIFT was found in 13.3% of study group; while none of the control group has positive GIFT. The significant variables among patients with low TLC included low ANC (OR: 5.0, 95% CI: 1.5-16.5, low HB (OR: 7.0, 95% CI: 1.4-35.5), and low PLT count (OR: 15.5, 95% CI: 3.8-63.3). Conclusion:AIN is significantly higher among CHC patients with low TLC compared to normal TLC patients.
 
Keywords
low total leucocytic count; Granulocyte Immuno-Fluorescence Test
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