ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE
SMA, E., EA, A., HM, O., TH, E. (2014). ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE. EKB Journal Management System, 20(4), 1-9. doi: 10.21608/zumj.2014.4405
El-Shazly SMA; Abdel-Gawad EA; Omar HM; El-Khatib TH. "ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE". EKB Journal Management System, 20, 4, 2014, 1-9. doi: 10.21608/zumj.2014.4405
SMA, E., EA, A., HM, O., TH, E. (2014). 'ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE', EKB Journal Management System, 20(4), pp. 1-9. doi: 10.21608/zumj.2014.4405
SMA, E., EA, A., HM, O., TH, E. ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE. EKB Journal Management System, 2014; 20(4): 1-9. doi: 10.21608/zumj.2014.4405

ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE

Zagazig University Medical Journal
Article 2, Volume 20, Issue 4, July 2014, Page 1-9  XML PDF (775.01 K)
Document Type: Original Article
DOI: 10.21608/zumj.2014.4405
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Authors
El-Shazly SMA1; Abdel-Gawad EA1; Omar HM2; El-Khatib TH1
1Neurology departments, Faculty of Medicine, Zagazig University
2clinical pathology departments, Faculty of Medicine, Zagazig University
Abstract
Background: Cerebral ischemia initiates an inflammatory response in the brain which is a composite process that involves many inflammatory mediators.The investigation of inflammatory response in the acute stage may contribute to improve the treatment of ischemic stroke. Objective: We assessed the relationship between peak values of serum interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1),erythrocyte sedimentation rate (ESR), c-reactive protein (CRP)and nitric oxide (NO)in the first week after ischemic stroke, with measures of stroke severity and outcome.Methods:forty-five patients (22 males and 23 females) with ischemic stroke were prospectively recruited. Serum IL-6, and other markers of peripheral inflammation, was measured at time points 24 h, as well 7 days after symptom onset.Twenty-five age-matched volunteers were used as controls. We correlated levels with stroke severity assessed by the NIH Stroke Scale; stroke outcome at 1 month assessed by BI and computed tomography (CT) brain infarct volume. Result(s): Peak serum IL-6 and CRP concentrations correlated significantly (p < 0.001) with CT brain infarct volume (r = 0.75) and NIHSS at 1 week (r = 0.72). They correlated similarly with clinical outcome at 1 month. Strong associations were also noted between either peak serum ICAM-1 or NO concentrations and short-term stroke outcome. Conclusion(s):These data provide evidence that the peripheral inflammatory response may be related to the severity of acute ischemic stroke, and may be used as predictors for clinical outcome.
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