Cutaneous CCL13 mRNA and protein expression in vitiligo; a new insight to its immunopathogenesis | ||
Suez Canal University Medical Journal | ||
Article 6, Volume 28, Issue 7, July 2025, Pages 42-52 PDF (421.74 K) | ||
Document Type: Original Article | ||
DOI: 10.21608/scumj.2025.440838 | ||
Authors | ||
Aya Mohamed Abd EL-Baset Morad* 1; Moustafa Mohamed Kamel Eyada1; hesham Ahmed nada1; Shymaa Ahmed Maher2; Wael Ahmed Maher3; Radwa El- Sayed Mahmoud Marie1 | ||
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||
2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||
3Clinical Sciences Department, College of Medicine, University of Sharjah, United Arab Emirates Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||
Abstract | ||
Background: Vitiligo is an acquired emotionally distressing skin depigmenting immune related disorder yielded by selective melanocyte death through type 1 immune response and an emerging participation of type 2 immune response. CCL13 is a hallmark in type 2 helper T cells immune-related skin diseases. Our previous study showed that CCL13 expression, a type 2 immune response marker, was higher in vitiligo patients than controls. Aim: To investigate the relationship between mRNA and protein expressions of CCL13 in vitiligo lesions. Subjects and methods: This cross-sectional study comprised 30 non-segmental marginal recent vitiligo lesions. Immunohistochemistry, and real-time polymerase chain reaction were used to assess CCL13 protein expression, and relative CCL13 mRNA gene expression, respectively. Results: CCL13 is expressed at both genetic and tissue levels as there is relation between mRNA and protein expressions of CCL13 in vitiligo lesions. Conclusion: Relation between mRNA and protein expressions of CCL13 in vitiligo lesions may suggest its positive participation in vitiligo immune pathogenesis | ||
Keywords | ||
Vitiligo; CCL13; autoimmune response | ||
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