Effect of Lycopene on Bisphenol A-induced Immunological Disturbances in Albino Male Rats
Abdelrazek, H., Eltamany, D., Soliman, M., Greish, S., Ebaid, H. (2019). Effect of Lycopene on Bisphenol A-induced Immunological Disturbances in Albino Male Rats. EKB Journal Management System, 22(1), 9-17. doi: 10.21608/scumj.2019.44180
Heba MA Abdelrazek; Dalia A Eltamany; Mohammed TA Soliman; Sahar M Greish; Hala M Ebaid. "Effect of Lycopene on Bisphenol A-induced Immunological Disturbances in Albino Male Rats". EKB Journal Management System, 22, 1, 2019, 9-17. doi: 10.21608/scumj.2019.44180
Abdelrazek, H., Eltamany, D., Soliman, M., Greish, S., Ebaid, H. (2019). 'Effect of Lycopene on Bisphenol A-induced Immunological Disturbances in Albino Male Rats', EKB Journal Management System, 22(1), pp. 9-17. doi: 10.21608/scumj.2019.44180
Abdelrazek, H., Eltamany, D., Soliman, M., Greish, S., Ebaid, H. Effect of Lycopene on Bisphenol A-induced Immunological Disturbances in Albino Male Rats. EKB Journal Management System, 2019; 22(1): 9-17. doi: 10.21608/scumj.2019.44180

Effect of Lycopene on Bisphenol A-induced Immunological Disturbances in Albino Male Rats

Suez Canal University Medical Journal
Article 2, Volume 22, Issue 1, March 2019, Page 9-17  XML PDF (580.95 K)
Document Type: Original Article
DOI: 10.21608/scumj.2019.44180
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Authors
Heba MA Abdelrazek1; Dalia A Eltamany2; Mohammed TA Soliman3; Sahar M Greish email 4; Hala M Ebaid5
1Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
2Department Home Economic, Nutrition and Food Science, Faculty of Education, Suez Canal University, Ismailia, Egypt.
3College of Applied Medical Sciences, Department of Medical Laboratory Sciences, University of Bisha, Kingdom of Saudi Arabia.
4Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
5Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt
Abstract
Background: Bisphenol A (BPA) is a widely used and environmentally spread plasticizer. BPA has various toxic effects, including immunological alterations. Aim: Current work aimed to investigate the effect of BPA and protection with lycopene (LYC) on immunological parameters. Material and Methods: Twenty-four male albino were divided into 4 equal groups. Control group received corn oil, LYC group was given LYC 5 mg/kg,BPA group was given BPA at 5 mg/kg. Last group was given combination of BPA and LYC the same previous doses. Treatments were given daily via oral gavage for 4 weeks. Weight gain, food conversion ratio (FCR), hematological parameters and lymphocytes proliferation assay were determined. Serum total antioxidant capacity (TAC), malondialdehyde (MDA), interleukin-1β (IL-1β), Interleukin-12 (IL-12) and lymphocytes comet assay were evaluated. Spleen and thymus histopathological assessment was done. Results: BPA significantly (P<0.05) increased FCR while decreased lymphocytes proliferation than control group however, hematological parameters didn't alter. Serum TAC was significantly (P<0.05) reduced in BPA group than control group while MDA, IL-1β and IL-12 were significantly (p<0.05) increased than control group. Lymphocyte showed significant increase in comet tail and % of damage. Thymus and spleen revealed mild lymphoid depletion. Conclusion: BPA induced immunological perturbations that favors pro-inflammation and autoimmunity. LYC administration ameliorated oxidative stress and lipid peroxidation induced immunological disorders.
 
Keywords
antioxidant; bisphenol A; Cytokines; hematology; lycopene
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