Alpha Pinene Mitigates Cisplatin Induced Acute Kidney Failure | ||
| The Medical Journal of Cairo University | ||
| Volume 93, Issue 06, June 2025, Pages 523-528 PDF (185 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2025.443857 | ||
| Author | ||
| ALAA A. ELGENDY, M.Sc.; HISHAM A. NEMATALLA, Ph.D.; MONA ELHAROUN, Ph.D. IHAB T. ABDEL-RAHEEM, Ph.D. | ||
| The Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University | ||
| Abstract | ||
| Background: Cisplatin is a very effective chemotherapy drug that is used to treat a wide range of malignancies. Its ther-apeutic efficacy is limited by tumor resistance and significant adverse effects that are connected to the dose, including hear-ing and renal impairment, as well as decreased bone marrow function. Aim of Study: Alpha-pinene’s nephroprotective efficacy against cisplatin-induced nephrotoxicity rats was the focus of this investigation. Material and Methods: 24 Sprague-Dawley male rats were separated into three groups (n=8), (1) Normal group, (2) Model group (cisplatin 7.5mg/kg, single dose, intraperitoneal), (3) α-Pinene group (50mg/kg, p.o. for 18 days). Cisplatin was administrated to all groups on day 15, excluding the normal group. Kidney function markers, antioxidant status, and inflam-matory marker were analyzed. Results: Cisplatin elevated kidney function markers and inflammatory markers. Further, the antioxidant level was sig-nificantly diminished in model group.The results showed that alpha-pinene pretreatment boosted antioxidant status while dramatically lowering renal function markers and inflammato-ry markers. Conclusion: Alpha-pinene has strong antioxidant and an-ti-inflammatory features, which protect against CP-induced nephrotoxicity. | ||
| Keywords | ||
| Cisplatin; Acute Kidney Injury; α-Pinene | ||
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