Propolis Extract Attenuates Sepsis-Induced Hepatotoxicity and Neurotoxicity in Male Rats | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 1, Volume 11, Issue 3, December 2019, Page 1-19 PDF (1.36 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2019.44505 | ||||
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| Authors | ||||
| Abdelmoneim Ahmed Esmat1; Sahar Mohamed Mahmoud2; Abd-Elrazek Areeg Mohamed3; El-Sisi Suzan Fahmy3; Mohammed Inas Salah3; El-Yamany Nabil Ahmed1 | ||||
| 1Entomology & Zoology Department, Faculty of Science, Helwan University | ||||
| 2Zoology Department, Faculty of Science, Cairo University | ||||
| 3Department of Physiology, National Organization for Drug Control and Research (NODCAR) | ||||
| Abstract | ||||
| Inflammation is an important biological event in host defenses against bacterial or viral infections. However, excessive inflammatory responses by aberrantly activated macrophages, producing excess amounts of inflammatory mediators, which disrupt immune homeostasis and result in immunopathological conditions such as sepsis. Sepsis was recognized as a systemic inflammatory response syndrome after serious infections, most commonly with bacteria, which have a high mortality rate. Propolis (Prop) could be used as adjuvant therapy in the management of sepsis. The present study aimed to investigate the protective effect of Prop against sepsis-induced in rats. Evaluation of complete blood count, activity of liver function enzymes in serum; alanine and aspartate aminotransferases were recorded. Oxidant/antioxidant markers in liver tissue namely; malonaldehyde, nitrites/nitrates, glutathione disulfide, glutathione levels, catalase and superoxide dismutase activities. Also, tumor necrosis factor-alpha and prostaglandin E-2 levels in both serum and liver tissue were estimated. Furthermore, interleukin-8, cyclooxygenase-2 and inducible nitric oxide synthase genes expression were determined. Histopathological examination of liver tissue was investigated. Brain neurotransmitters; Dopamine, Norepinephrine and 5-hydroxytryptamine were also determined against sepsis-induced inflammation. The present study indicated that Prop could be an efficient protector that resets sepsis-induced severe oxidative stress, inflammation and improve the immune response of the liver as well as septic neurotoxic problems. | ||||
| Keywords | ||||
| Sepsis; Propolis; Oxidative Stress; Inflammation, Monoamines | ||||
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