In Vitro Study of Anticancer Effect of N Acetyl Cysteine –Metal Complexes as New Target Drugs on Human Cancer Cell Lines
A. R. AbouZaid, O., Noaman, E., abdelAti, S., Mohamed, G. (2018). In Vitro Study of Anticancer Effect of N Acetyl Cysteine –Metal Complexes as New Target Drugs on Human Cancer Cell Lines. EKB Journal Management System, 34(3), 206-217. doi: 10.21608/bvmj.2018.44746
Omayma A. R. AbouZaid; Eman Noaman; Shaimaa abdelAti; Gehad Genidy Mohamed. "In Vitro Study of Anticancer Effect of N Acetyl Cysteine –Metal Complexes as New Target Drugs on Human Cancer Cell Lines". EKB Journal Management System, 34, 3, 2018, 206-217. doi: 10.21608/bvmj.2018.44746
A. R. AbouZaid, O., Noaman, E., abdelAti, S., Mohamed, G. (2018). 'In Vitro Study of Anticancer Effect of N Acetyl Cysteine –Metal Complexes as New Target Drugs on Human Cancer Cell Lines', EKB Journal Management System, 34(3), pp. 206-217. doi: 10.21608/bvmj.2018.44746
A. R. AbouZaid, O., Noaman, E., abdelAti, S., Mohamed, G. In Vitro Study of Anticancer Effect of N Acetyl Cysteine –Metal Complexes as New Target Drugs on Human Cancer Cell Lines. EKB Journal Management System, 2018; 34(3): 206-217. doi: 10.21608/bvmj.2018.44746

In Vitro Study of Anticancer Effect of N Acetyl Cysteine –Metal Complexes as New Target Drugs on Human Cancer Cell Lines

Benha Veterinary Medical Journal
Article 17, Volume 34, Issue 3, August 2018, Page 206-217  XML PDF (781.48 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2018.44746
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Authors
Omayma A. R. AbouZaid1; Eman Noaman2; Shaimaa abdelAti3; Gehad Genidy Mohamed4
1Biochemistry Department, Faculty of Vet. Med. Moshtohor, Benha University, Egypt
2Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Egypt.
3Inorganic Chemistry Dept., Faculty of Science, Cairo University.
4Post graduate student
Abstract
 One of the main methods of modern cancer treatment is drug therapy but, it is found to be difficult to cure effectively. N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of different metals. In the present study synthesis of NAC with (Cu, Zn, Cd, Fe, Mg, Mn, Cr, Ni, Co, Se and Ag) by metals investigation and the formation of these complexes by IR, NMR. The effect of cytotoxicity of these complexes on Breast, Liver, Prostate and Ovary human cancer cell lines were evaluated. The best complexes were seen in cadmium N acetyl cysteine complex in breast, ovary, prostate and liver cell line. 
Keywords
N acetyl cysteine; Metal complexes; IR; NMR; human cancer cell line
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