The potential anticancer effect of [Cadmium-N Acetyl cysteine] as novel drug therapy for mammary cancer induced by Di Methyl Benzene Anthanthrene in rats | ||||
| Benha Veterinary Medical Journal | ||||
| Article 19, Volume 34, Issue 3, August 2018, Page 232-245 PDF (481.41 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2018.44748 | ||||
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| Authors | ||||
| Omayma A.R. AbouZaid1; Eman Noaman2; Shaimaa abdel-Ati1; Gehad Genidy Mohamed3 | ||||
| 1Biochemistry Department, Faculty of Vet. Med. Moshtohor, Benha University, Egypt. | ||||
| 2Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Egypt. | ||||
| 3Professor of Inorganic Chemistry, Faculty of Science Cairo University. | ||||
| Abstract | ||||
| The discovery of Cisplatin triggered the development of novel drugs containing other metals. Extremely diverse structural Chemistry and interaction of metal with ligand resulted in exploration of novel metal complexes with drug potential. The present work carried on 80 female rats which divided into four groups, after 12 weeks the mammary tumor appeared the possible anti-cancer effect of (Cadmium-N Acetyl Cysteine) which has been synthesized and study its effect on (Cd44, Cyclin D1, p21, caspase3, caspase 9 and cell cycle) were investigated on bearing solid mammary tumor induced by DMBA in rats | ||||
| Keywords | ||||
| Metal complex- CD44-Cyclin D1-Caspase-ligand | ||||
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