Template Synthesis, Spectral and Thermal Properties of Nd(III) Metformin Schiff-Base Complexes As Potential Hypoglycemic Agents
Mahmoud, M., Abou-elmagd, M. (2020). Template Synthesis, Spectral and Thermal Properties of Nd(III) Metformin Schiff-Base Complexes As Potential Hypoglycemic Agents. EKB Journal Management System, 63(3), 1009-1031. doi: 10.21608/ejchem.2019.13640.1858
Marwa Mahmoud; Mahmoud Abou-elmagd. "Template Synthesis, Spectral and Thermal Properties of Nd(III) Metformin Schiff-Base Complexes As Potential Hypoglycemic Agents". EKB Journal Management System, 63, 3, 2020, 1009-1031. doi: 10.21608/ejchem.2019.13640.1858
Mahmoud, M., Abou-elmagd, M. (2020). 'Template Synthesis, Spectral and Thermal Properties of Nd(III) Metformin Schiff-Base Complexes As Potential Hypoglycemic Agents', EKB Journal Management System, 63(3), pp. 1009-1031. doi: 10.21608/ejchem.2019.13640.1858
Mahmoud, M., Abou-elmagd, M. Template Synthesis, Spectral and Thermal Properties of Nd(III) Metformin Schiff-Base Complexes As Potential Hypoglycemic Agents. EKB Journal Management System, 2020; 63(3): 1009-1031. doi: 10.21608/ejchem.2019.13640.1858

Template Synthesis, Spectral and Thermal Properties of Nd(III) Metformin Schiff-Base Complexes As Potential Hypoglycemic Agents

Egyptian Journal of Chemistry
Article 94, Volume 63, Issue 3, March 2020, Page 1009-1031  XML PDF (2.82 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.13640.1858
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Authors
Marwa Mahmoud email orcid 1; Mahmoud Abou-elmagd2
1Department of science and Mathematics Engineering, Faculty of petroleum and Mining Engineering, Suez University, Suez, Egypt
2Holding Company for Water and Wastewater, Ismailia, Egypt.
Abstract
ND(III) complexes with Schiff-bases obtained by condensation of metformin with each of salicylaldehyde (HL1); 2,3- dihydroxybenzaldehyde (H2L2); 2,4-dihydroxybenzaldehyde (H2L3); 2,5- dihydroxybenzaldehyde (H2L4) and 3,4-dihydroxybenzaldehyde (H2L5); and 2-hydroxynaphthaldehyde (HL6) have been synthesized using the template reaction. The complexes were characterized by elemental analysis, conductivity and magnetic moment measurements, IR, UV-Vis., emission, GC-MS and XRD spectroscopy and thermal analysis. The complexes are eight coordinated structure with formulae [NdL1-4,6(NO3)2(H2O)3].nH2O where n = 2, 3, 3, 4, 5 and [NdL5(NO3)(H2O)5].2H2O. The nitrate appears to coordinate in the monodentate fashion to the metal ion. The complexes have hexagonal bipyramide stereochemistry as shown by the UV-Vis spectra and molecular modeling calculations. The thermal stabilities of the complexes have been studied by TGA, DTG and DTA and Coats-Redfern method was used to calculate their kinetic parameters. The mechanism of thermal decomposition was suggested using IR spectra at different temperatures. The association constants (Kb) for the interaction of glucose with the complexes were calculated at physiologically relevant pH (phosphate buffer) using UV-Vis and fluorescence spectroscopy as well as viscosity measurements.
Keywords
Glucose sensor; Metformin Schiff-bases; Nd(III) complexes; Spectral and thermal properties
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