Hyperdopaminergic Manifestations in Parkinson’s Disease: Correlation between Impulse Control Disorders and Levodopa- Induced Dyskinesia | ||
| Ain Shams Medical Journal | ||
| Volume 76, Issue 2, June 2025, Pages 472-481 PDF (376.92 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2025.357811.1383 | ||
| Authors | ||
| ALIA H MANSOUR* 1; Ahmed H .Ammar2; Ahmed A. Gaber3; Shima Ebrahim4; Heba M Khafaga5 | ||
| 1Neurology Department , Faculty of Medicine, Ain Shams University | ||
| 2Sohag General Hospital | ||
| 3Neurology department , Ain Shams University , Faculty of Medicine | ||
| 4Faculty of Medicine, Ain Shams University | ||
| 5Neurology Department, Faculty of Medicine, Ain Shams University | ||
| Abstract | ||
| Objective: To explore the relationship between levodopa-induced dyskinesia and impulse control disorders (ICDs) in Parkinson’s disease (PD), exploring the hyperdopaminergic motor and non-motor state. Methods: A cross-sectional study was conducted on 30 PD patients with dyskinesia. All Participants were assessed by motor and non-motor validated scales. These included the third part of the Unified Parkinson’s Disease Rating Scale owned by the movement disorders society MDS-UPDRS III, The Unified Dyskinesia rating scale (UDysRS) , Non -Motor symptoms scale for Parkinson’s disease (PD NMSS) in addition to dopamine dysregulation syndrome and impulse control disorders, cognition, depression and anxiety . Results: The study group had a mean age of 58 ± 6.9 years, with 76.7% males. The mean disease duration was 8.8 ± 4 years. Impulse control disorders (ICDs) were observed in 60% of patients, with excessive medication intake being the most common. All patients had moderate to severe motor symptoms, while the majority exhibited severe to very severe non-motor manifestations. A weak non-significant correlation (r = 0.194, p = 0.304) was found between levodopa-induced dyskinesia assessed by UDysRS and Impulse control disorders assessed by the Questionnaire for impulsive compulsive disorders in Parkinson’s disease (QUIP-RS), suggesting a possible association between both conditions. Conclusion: While a non-significant positive correlation between dyskinesia and impulse control disorders was identified, further studies are needed to explore the complex interplay between hyperdopaminergic motor and non-motor symptoms in Parkinson’s disease. | ||
| Keywords | ||
| Impulse control disorders; levodopa induced dyskinesia; levodopa equivalent dose; Non- Motor; Parkinson's | ||
|
Statistics Article View: 69 PDF Download: 23 |
||
