Teratogenic effects of aflatoxin in Rabbits (Oryctolagus cuniculus)
El-Nahla, S., Imam, H., Moussa, E., Ibrahim, A., Ghanam, A. (2013). Teratogenic effects of aflatoxin in Rabbits (Oryctolagus cuniculus). EKB Journal Management System, 6(2), 67-85. doi: 10.21608/jva.2013.45024
S. M. El-Nahla; H. M. Imam; E. A. Moussa; A. M. Ibrahim; A. R. Ghanam. "Teratogenic effects of aflatoxin in Rabbits (Oryctolagus cuniculus)". EKB Journal Management System, 6, 2, 2013, 67-85. doi: 10.21608/jva.2013.45024
El-Nahla, S., Imam, H., Moussa, E., Ibrahim, A., Ghanam, A. (2013). 'Teratogenic effects of aflatoxin in Rabbits (Oryctolagus cuniculus)', EKB Journal Management System, 6(2), pp. 67-85. doi: 10.21608/jva.2013.45024
El-Nahla, S., Imam, H., Moussa, E., Ibrahim, A., Ghanam, A. Teratogenic effects of aflatoxin in Rabbits (Oryctolagus cuniculus). EKB Journal Management System, 2013; 6(2): 67-85. doi: 10.21608/jva.2013.45024

Teratogenic effects of aflatoxin in Rabbits (Oryctolagus cuniculus)

Journal of Veterinary Anatomy
Article 5, Volume 6, Issue 2, October 2013, Page 67-85  XML PDF (1.29 MB)
Document Type: Original Article
DOI: 10.21608/jva.2013.45024
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Authors
S. M. El-Nahla1; H. M. Imam1; E. A. Moussa1; A. M. Ibrahim2; A. R. Ghanam1
1Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;
2Department of pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;
Abstract
This study was conducted to determine the teratogenic effects of aflatoxin B1 (AFB1) in balady rabbits. The female animals divided into two groups control and treated, each group contained three dams. A dose of 0.05mg /kg/day AFB1 was administered by gastric intubation to pregnant rabbits on the 6th–18th day of pregnancy. The fetuses were obtained through the uterine incision at 29th day of gestation. The lengths and weights of the fetuses as well as absolute organs weights were measured, revealing the statistically significant differences between the two groups (p<0.001).The observed gross anomalies included wrinkled skin, enlarged eye socket and microphthalmic eyes. The heart of treated group showed reduction in size with wide ventricular lumen and shallow inter ventricular groove. The characteristic fetal histopathological findings were vaccuolation and distortion of hepatic cord pattern. The renal tubular epithelium was vacuo- lated and their lumen were occluded with casts. The eye lids revealed less number of hair follicles. Regarding, the skeletal anomalies there were incomplete ossification in some of the skull bones, the lami- nae of the vertebral arches throughout the vertebral column remain cartilaginous. The sternum was incompletely ossified. The 2nd phalanx, carpus, extremities of metacarpi had no cartilaginous drafts. The central and distal tarsal rows as well as extremities of metatarsi remained car- tilaginous..
Keywords
Aflatoxin B1 (AFB1); Rabbits; teratogenicity; Ossification; histopathology
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