Serum and Urine Neutrophil Gelatinase- Associated Lipocalin: As an Indicator for Early Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients
Abd el kader, O., ismail, M., borai, M., ragab, W. (2020). Serum and Urine Neutrophil Gelatinase- Associated Lipocalin: As an Indicator for Early Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients. EKB Journal Management System, 26(3), 474-482. doi: 10.21608/zumj.2019.13529.1249
Omar Mohamed El sayed Abd el kader; mabrouk ibrahim ismail; maher mohamed borai; walid ahmed ragab. "Serum and Urine Neutrophil Gelatinase- Associated Lipocalin: As an Indicator for Early Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients". EKB Journal Management System, 26, 3, 2020, 474-482. doi: 10.21608/zumj.2019.13529.1249
Abd el kader, O., ismail, M., borai, M., ragab, W. (2020). 'Serum and Urine Neutrophil Gelatinase- Associated Lipocalin: As an Indicator for Early Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients', EKB Journal Management System, 26(3), pp. 474-482. doi: 10.21608/zumj.2019.13529.1249
Abd el kader, O., ismail, M., borai, M., ragab, W. Serum and Urine Neutrophil Gelatinase- Associated Lipocalin: As an Indicator for Early Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients. EKB Journal Management System, 2020; 26(3): 474-482. doi: 10.21608/zumj.2019.13529.1249

Serum and Urine Neutrophil Gelatinase- Associated Lipocalin: As an Indicator for Early Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients

Zagazig University Medical Journal
Article 14, Volume 26, Issue 3, May 2020, Page 474-482  XML PDF (981.68 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.13529.1249
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Authors
Omar Mohamed El sayed Abd el kader email orcid 1; mabrouk ibrahim ismail2; maher mohamed boraiorcid 3; walid ahmed ragaborcid 2
1Internal medicine,faculty of medicine,Zagazig university,Zagazig,egypt
2internal medicine,faculty of medicine,zagazig university,zagazig,egypt
3clinical pathology,faculty of medicine,zagazig university,zagazig, egypt
Abstract
Abstract
Background: Diabetic Kidney Disease (DKD) represents the major cause Chronic Kidney Disease (CKD) where 5- 40% of patients with Type 2 Diabetes Mellitus (T2DM) ultimately develop DKD. CKD diagnosis is reliable on levels of blood urea nitrogen and serum creatinine, however, serum creatinine has a low predictive value in early detection of renal impairment. So, new biomarkers for early diagnosis of CKD is of interest. Objectives: Elucidate the significance of Neutrophil Gelatinase- Associated Lipocalin (NGAL) as an early predictor of diabetic nephropathy in comparison with albuminuria in (T2DM). Patients and Methods: Prospective, case control study, carried out on patients with T2DM with a duration of disease ranged from (5-15) years, presented to outpatient clinics of nephrology and endocrinology units of internal medicine department in Zagazig University hospitals from August 2018 to February 2019., The study included (100) participants divided into : group (A) 25 healthy control , group (B) 75 diabetic type 2 patients stratified into three subgroups according to albumin / creatinine ratio: subgroup (1) : 25 normoalbuminuric ,subgroup (2): 25 microalbuminuric subgroup (3) : 25 macroalbuminuric. Results: there was statistically significant difference between healthy individuals, normo, micro and macroalbuminuria diabetic patients regarding serum NGAL (sNGAL) & urinary NGAL (uNGAL),where their levels incremented parallel to the degree of albuminuria . Conclusion: tubular injury may precede glomerular injury in diabetic patients and As NGAL is a tubular marker , So NGAL is superior to albumin / Creatinine ratio(ACR) as an early predictor of DKD among T2DM patients .
Keywords
Key words: Chronic kidney disease; Body Mass Index; Acute kidney injury
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