BLEOMYCIN INDUCED –INTERSTITIAL PULMONARY FIBROSIS IN MICE | ||||
| Zagazig University Medical Journal | ||||
| Article 7, Volume 21, Issue 3, May 2015, Page 1-4 PDF (606.63 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2015.4522 | ||||
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| Authors | ||||
| Sayed Abdelhafez1; Mohammad Abu Shehata2; Fatma Mostafa3; Amal Mostafa1; Heba Essa4 | ||||
| 1Department of chest, Faculty of Medicine, Mansoura University | ||||
| 2Department of chest , Faculty of Medicine, Mansoura University | ||||
| 3Department of pathology, Faculty of Medicine, Mansoura University | ||||
| 4Department of chest,Faculty of Medicine, Mansoura University | ||||
| Abstract | ||||
| Background and objectives: The uses of animal models in researches of pulmonary fibrosis depend on the presence of structural, biochemical, and molecular similarity between fibrotic reaction in humans and animals. The aim of this study was to evaluate the ability of bleomycin to induce interstitial pulmonary fibrosis in mice.Material and methods: This study was conducted on C57BL/6 mice (14). Normal C57BL/6 mice (6) received 0.25 ml normal saline intraperotineal twice weekly for 8 weeks and sacrificed two days after last saline dose injection.8 mice received intraperotineal injection of 0.5mg bleomycin twice weekly for 8 weeks only 6 mice completed the study and sacrificed two days after last bleomycin dose. Weight recorded once weekly.Results: bleomycin induced fibrosis in the animal model after eight weeks with p<0.001Conclusion: bleomycin in a dose of 0.5mg for 8weeks induce pulmonary fibrosis in C57BL/6 MICE | ||||
| Keywords | ||||
| Bleomycin; intraperotineal injection; interstitial pulmonary fibrosis | ||||
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