HISTOPATHOLOGICAL EFFECT OF SPIRULINA IN RENAL ISCHEMIA REPERFUSION IN RATS | ||||
| Zagazig University Medical Journal | ||||
| Article 7, Volume 21, Issue 4, July 2015, Page 1-7 PDF (1014.66 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2015.4547 | ||||
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| Authors | ||||
| Dina Abd- Allah1; Azza Abdel-Aziz1; Amira El-Hawary2; Fatma El- Husseini2; Soheir Sirag | ||||
| 1Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||||
| 2Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. | ||||
| Abstract | ||||
| Background/Aim: Ischemia/reperfusion (I/R) injury occurs in renal transplantation, and it could be a risk factor for late renal allograft failure. Several exogenous antioxidants used in prevention of renal I/R injury. Multiple experimental studies demonstrated the antioxidant effect of Spirulina. This study focused on the effects of Spirulina on histopathology of kidney subjected to I/R injury. Methods: Renal I/R was induced in male Sprague-Dwaley rats by occluding the left renal artery then right nephrectomty. Group I was sham operated rats; group II, control (non treated rats); and group III, Spirulina-treated rats (1000 mg/kg BW, orally. 7 days before I/R). Rats were sacrificed 1 & 3 days post reperfusion. The effects of Spirulina on both necrosis and regeneration of kidney tubules caused by renal I/R injury were assayed and scored. Results: Spirulina pretreatment decrease the necrotic injury and improve tubular regeneration after 1 and 3days of renal I/R injury. Conclusion: Spirulina decreased the necrotic activity index in rat kidney after I/R injury and help in tubular regeneration. | ||||
| Keywords | ||||
| Spirulina; ischemia reperfusion (I/R) injury; acute renal failure; outer strip outer medulla (OSOM); necrosis, tubular regeneration | ||||
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