Ameliorative impact of epigallocatechin-3-gallate against methionine induced toxicity | ||
| Mansoura Journal of Biology | ||
| Volume 57, Issue 4, December 2022, Pages 41-49 PDF (943.08 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2022.456244 | ||
| Authors | ||
| Mostafa D. Mostafa* ; Magda ElKomy; Mohamed A. El-Missiry | ||
| Zoology Department, Faculty of Science, Mansoura University, Egypt. | ||
| Abstract | ||
| Hyperhomocysteinemia (HHcy) is associated with a variety of pathological processes. Epigallocatechin-3-gallate (EGCG), a plentiful catechin found in green tea, is a powerful natural antioxidant with a multitude of biological advantage The objective of this study was to determine whether EGCG could counteract liver function alterations brought on by methionine (Met). Met was infused into drinking water (1g/kg body weight) for 35 days to induce HHcy in adult male mice. In addition to Met, EGCG (5mg/kg body weight) was given orally every day. While IL-10 levels in serum of the Met group considerably decreased as compared to the control group, VCAM-1 and ICAM-1 serum levels were found to be greater in the Met group than in the control group. By improving the adhesion molecules VCAM-1 and ICAM-1 and increasing the anti-inflammatory cytokine IL-10, EGCG substantially reduces inflammation. The ALT, AST, and bilirubin levels in the serum considerably elevated whereas albumin and total protein levels dropped significantly in the HHcy mice treated with Met. EGCG improved albumin, total protein, ALT, AST, and total bilirubin, which helped to correct liver function markers. In conclusion, HHcy induction by Met cause liver parameter alterations and inflammation. The liver's biochemical changes brought on by HHcy can be significantly prevented by EGCG. | ||
| Keywords | ||
| Methionine; liver injury; inflmmation; hyperhomocysteinemia | ||
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