Interferon-ë rs12979860CC genotype predicts sustained virological response to therapy in patients with chronic hepatitis C Genotype 4 but enhances hepatic fibrosis | ||||
| Medical Journal of Viral Hepatitis | ||||
| Article 1, Volume 1.2, Issue 2, June 2016, Page 1-12 PDF (250.43 K) | ||||
| Document Type: Original article | ||||
| DOI: 10.21608/mjvh.2016.4566 | ||||
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| Authors | ||||
| Shiha G.1; Samir W.2; Seif S.1; Soliman R.3; Zalata K.4; Helmy A.5 | ||||
| 1Internal Medicine dept., Faculty of Medicine, Mansoura Univ., Egypt. ,Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt. | ||||
| 2Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt. ,Biochemistry dept., Faculty of Medicine, Mansoura Univ., Mansoura, Egypt | ||||
| 3Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt. | ||||
| 4Cairo, Pathology dept., Faculty of Medicine, Mansoura Univ., Egypt. | ||||
| 5Tropical Medicine & Gastroenterology, dept., Faculty of Medicine, Assiut Univ., Assiut, Egypt. | ||||
| Abstract | ||||
| Recently, several genome wide association studies (GWAS) have revealed that several single nucleotide polymorphisms (SNPs) in proximity to the interleukin (IL)-28B genes can predict spontaneous clearance of hepatitis C virus (HCV) infection as well as sustained virological response (SVR) to Pegylated interferon-2a/b plus ribavirin therapy. In HCV-genotype 1 patients, the allele rs12979860 is associated with greater hepatic necro-inflammation and worse clinical outcome, but lower fibrosis progression. Data on patients infected with HCV genotype 4 (G4) is limited. The present study assesses the impact of rs12979860 IL28 SNP on hepatic fibrosis and SVR in patients with chronic HCV G4 infection. A total of 163 patients with chronic HCV G4 infection (123 males and 40 females) who had pre-treatment liver biopsy were included. Both HCV RNA and IL28 rs12979860 genotypes were determined by real time polymerase chain reaction. Hepatic fibrosis, IL28B rs12979860 genotype, and SVR were statistically correlated together and with various clinical, biochemical, and virological parameters. All patients were found to be infected with HCV G4. IL28B rs12979860 genotypes TT, CT, and CC were detected in 29 (17.8%), 107 (56.6%), and 27 (16.6%) patients, respectively. SVR was achieved in 85 (52.1%), severe fibrosis (≥F3) by METAVIR score was found in 75 (64.0%). The CC allele is associated with nearly twice (OR=1.898) the risk for having severe fibrosis (≥F3), but nearly 16 times SVR (OR=15.833) than having CT and TT. Contrary to HCV G1, the CC allele at IL28B rs12979860 appears to be associated with higher hepatic fibrosis, but better SVR to therapy in patients with chronic HCV G4 infection. | ||||
| Keywords | ||||
| Chronic hepatitis C; Genotype 4; Interleukin-28B; Hepatic fibrosis; Genetics | ||||
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