Comparison between Transient Elastography (FibroScan) and Liver Biopsy for the Diagnosis of Hepatic Fibrosis in Chronic Hepatitis C Patients | ||||
| Medical Journal of Viral Hepatitis | ||||
| Article 3, Volume 2.1, Issue 1, November 2016, Page 1-9 PDF (191.61 K) | ||||
| Document Type: Original article | ||||
| DOI: 10.21608/mjvh.2016.4571 | ||||
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| Authors | ||||
| Shiha G.1; El-Etreby S.2; Bahgat M.2; Hamed M.2; El Sherbini M2; Ghoneem EA.3; Zalata K.4; Soliman R.5; El-Basiouny M.1; Mikhail NNH.6 | ||||
| 1Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt, Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine,El-Mansoura University, Egypt | ||||
| 2Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine,El-Mansoura University, Egypt | ||||
| 3Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine, El-Mansoura University, Egypt | ||||
| 4Pathology Department, Faculty of Medicine, El-Mansoura University, Egypt | ||||
| 5Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt | ||||
| 6Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt,Department of Biostatistics, South Egypt Cancer Institute, Assiut University, Egypt | ||||
| Abstract | ||||
| Transient elastography (TE) is gaining popularity as a non-invasive method for predicting liver fibrosis. The practical utility of the method is based on establishing cutoff values for each stage of fibrosis. A diagnosis of stage is based on measurements of liver stiffness that vary in different studies. The present study aimed to establish cutoff values for each stage of fibrosis to assess the performance of TE in fibrosis staging in Egyptian chronic HCV patients. This cross-sectional study was conducted at Specialized Medical Hospital and the Egyptian Liver Foundation, Mansoura, Egypt. The inclusion criteria were: age older than 18 years and chronic infection by hepatitis C. The exclusion criteria were the presence of ascites, pacemaker or pregnancy. Three hundred and fifty six consecutive patients with chronic hepatitis C participated in the study. Liver fibrosis was staged according to the METAVIR system. The AUROCs for F2 or greater, F3 or greater and cirrhosis (F4) were 0.91 (95% CI 0.87 to 0.94), 0.95 (95% CI 0.91 to 0.99) and 0.97 (95% CI 0.96 to 0.99), respectively. ROC curve analysis identified optimal cutoff value of liver stiffness measurements as high as 9.8 kPa for F ≥ 2, 10.4 kPa for F ≥ 3, and 17.2 kPa for F = 4. The overall relation between fibrosis stages when comparing both FibroScan and biopsy was significant agreement between both (the kappa measure was 0.430 and p<0.001). TE is a good non-invasive tool for diagnosis and monitoring of liver fibrosis among patients with Chronic HCV infection. | ||||
| Keywords | ||||
| Transient elastography; FibroScan; Liver Biopsy; Chronic hepatitis C | ||||
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