Antioxidant Status in Children with Nephrotic Syndrome
Atwa, H., Nour El-Din, A., Abbas, F., Ahmed, A. (2004). Antioxidant Status in Children with Nephrotic Syndrome. EKB Journal Management System, 4(1), 53-60. doi: 10.21608/geget.2004.45809
Hoda Atwa; Abeer Nour El-Din; Faten Abbas; Amal Ahmed. "Antioxidant Status in Children with Nephrotic Syndrome". EKB Journal Management System, 4, 1, 2004, 53-60. doi: 10.21608/geget.2004.45809
Atwa, H., Nour El-Din, A., Abbas, F., Ahmed, A. (2004). 'Antioxidant Status in Children with Nephrotic Syndrome', EKB Journal Management System, 4(1), pp. 53-60. doi: 10.21608/geget.2004.45809
Atwa, H., Nour El-Din, A., Abbas, F., Ahmed, A. Antioxidant Status in Children with Nephrotic Syndrome. EKB Journal Management System, 2004; 4(1): 53-60. doi: 10.21608/geget.2004.45809

Antioxidant Status in Children with Nephrotic Syndrome

GEGET
Article 6, Volume 4, Issue 1, August 2004, Page 53-60  XML PDF (937.73 K)
Document Type: Original Article
DOI: 10.21608/geget.2004.45809
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Authors
Hoda Atwa1; Abeer Nour El-Din1; Faten Abbas2; Amal Ahmed3
1Departments if Paediatrics, Faculty of Medicine, Suez Canal University, Egypt.
2National Research Center, Department of Physiology, Egypt.
3Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt.
Abstract
Background: It has long been recognized that primary childhood nephrotic syndrome (NS) is an immunological disorder. In recent years it has been proposed that NS is a consequence of an imbalance between oxidant and antioxidant activity. Reactive oxygen metabolites play an important role in the pathophysiologic process of a surprisingly wide variety of clinical and experimental renal diseases.
Objectives: The aim of the present study was to examine the activity of the main antioxidant enzymes and the total antioxidant status in children with NS.
Methods: The study included three groups of children. Group I included 20 children during the proteinuric phase of nephrotic syndrome. Group II included 20 children, 6 months after remission which was induced by steroid therapy. The age range was 4-10 years, with a mean of 6.2 ± 1.4 years. Group III included 20 healthy children, matched for age and sex as a control group. Total antioxidant status (TAS), glutathione reductase (GR) and glutathione peroxidase (GPX) were measured for all.
Results: TAS was significantly reduced in both group I and group II compared to the control (p=0.01). In children from Group I the activity of GR and GPX were significantly lower than in controls. In children from Group II GR activity was also significantly lower than in the control group (p=0.006), but there was no significant difference in GXP level. The activity of TAS & GXP were lower in those with first attack of NS (Group I) and those in remission (Group II). There was no significant difference in GR level between Children in Group I and those in Group II. The total cholesterol (TChol) and low density lipoprotein cholesterol (LDL) concentrations in Group I were significantly higher than those in Group II and in the controls. There was no significant differences in high density lipoprotein cholesterol (HDL) & triglyceride (TG) levels in the two Groups I& II. In children with first attack NS a negative correlation appeared between TAS and TChol and LDL. There was no correlation between TAS and other laboratory results. In children with remission there was a negative correlation between TChol and TAS. But no correlation between TAS and other laboratory results.
Conclusions: We concluded that total antioxidant status is diminished in children with NS. Abnormal antioxidant status may be partly related to abnormalities of some antioxidant enzyme activity and high lipid concentration.  
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