Therapeutic Potential of Pomegranate and Annona muricata Linn. Fruit Juices in Aluminum Chloride-Induced Neurologic Dysfunction: Focus on Oxidative Stress
M. Ghonim, N., M. Rabeh, N., O. Aborya, A. (2025). Therapeutic Potential of Pomegranate and Annona muricata Linn. Fruit Juices in Aluminum Chloride-Induced Neurologic Dysfunction: Focus on Oxidative Stress. EKB Journal Management System, 41(3), 109-134. doi: 10.21608/jhe.2025.459326
Nancy M. Ghonim; Naeem M. Rabeh; Alaa O. Aborya. "Therapeutic Potential of Pomegranate and Annona muricata Linn. Fruit Juices in Aluminum Chloride-Induced Neurologic Dysfunction: Focus on Oxidative Stress". EKB Journal Management System, 41, 3, 2025, 109-134. doi: 10.21608/jhe.2025.459326
M. Ghonim, N., M. Rabeh, N., O. Aborya, A. (2025). 'Therapeutic Potential of Pomegranate and Annona muricata Linn. Fruit Juices in Aluminum Chloride-Induced Neurologic Dysfunction: Focus on Oxidative Stress', EKB Journal Management System, 41(3), pp. 109-134. doi: 10.21608/jhe.2025.459326
M. Ghonim, N., M. Rabeh, N., O. Aborya, A. Therapeutic Potential of Pomegranate and Annona muricata Linn. Fruit Juices in Aluminum Chloride-Induced Neurologic Dysfunction: Focus on Oxidative Stress. EKB Journal Management System, 2025; 41(3): 109-134. doi: 10.21608/jhe.2025.459326

Therapeutic Potential of Pomegranate and Annona muricata Linn. Fruit Juices in Aluminum Chloride-Induced Neurologic Dysfunction: Focus on Oxidative Stress

مجلة الاقتصاد المنزلي
Volume 41, Issue 3, September 2025, Pages 109-134    PDF (433.7 K)
Document Type: المقالة الأصلية
DOI: 10.21608/jhe.2025.459326
Authors
Nancy M. Ghonim1; Naeem M. Rabeh2; Alaa O. Aborya2
1Faculty of Home Economics, Helwan University
2Faculty of Nutrition Science, Helwan University
Abstract
Pomegranate (Punica granatum) and Annona Muricata linn fruit juices are rich in bioactive compounds with potent antioxidant and neuroprotective properties. Therefore, this Study was conducted to investigate the antioxidant activity of pomegranate and Annona Muricata fruit pulp juice on aluminum chloride induced rat neurologic disease model. Fifty adult male rats were randomly divided into five equal groups (n = 10 each). The first group (negative control) was fed on a basal diet. The other groups were injected with aluminum chloride (AlCl₃) to induce oxidative stress (OS), the second group (positive control) received basal diet. The other groups (3 : 5) were fed on a basal diet and given orally pomegranate juice (PJ), Annona Muricata juice (AMJ) and mixture of PJ and AMJ (1:1 v/v) at (1 ml/100 g body weight), respectively. The results demonstrated that administration of PJ and AMJ significantly (P<0.05) improved body weight status as compared to the positive control group. Liver functions and oxidative stress biomarkers including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX), and total antioxidant capacity (TAC) were significantly (P<0.05) ameliorated in the treated groups. These findings support the potential therapeutic application of both Pomegranate and Annona Muricata fruit juices through their antioxidant effects.
Keywords
Pomegranate; Annona Muricata; Aluminum chloride; Antioxidant; Oxidative stress; Liver function; Body weight; Rats
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