ROLE OF ß2 MICRO-GLOBULIN IN EARLY ASSESSMENT OF RENAL AFFECTION IN LEAD BATTERY WORKERSMINIA CITY
Mahmoud, A., Zaher, J., Hafez, M., Hasan, E., Mounir, A. (2017). ROLE OF ß2 MICRO-GLOBULIN IN EARLY ASSESSMENT OF RENAL AFFECTION IN LEAD BATTERY WORKERSMINIA CITY. EKB Journal Management System, 17(2), 13-25. doi: 10.21608/ejfsat.2017.46118
Asmaa Mohamed Mahmoud; Jaklin Fekri Zaher; Mohamed Ismail Hafez; Eman Ismail Hasan; Alia Mohamed Mounir. "ROLE OF ß2 MICRO-GLOBULIN IN EARLY ASSESSMENT OF RENAL AFFECTION IN LEAD BATTERY WORKERSMINIA CITY". EKB Journal Management System, 17, 2, 2017, 13-25. doi: 10.21608/ejfsat.2017.46118
Mahmoud, A., Zaher, J., Hafez, M., Hasan, E., Mounir, A. (2017). 'ROLE OF ß2 MICRO-GLOBULIN IN EARLY ASSESSMENT OF RENAL AFFECTION IN LEAD BATTERY WORKERSMINIA CITY', EKB Journal Management System, 17(2), pp. 13-25. doi: 10.21608/ejfsat.2017.46118
Mahmoud, A., Zaher, J., Hafez, M., Hasan, E., Mounir, A. ROLE OF ß2 MICRO-GLOBULIN IN EARLY ASSESSMENT OF RENAL AFFECTION IN LEAD BATTERY WORKERSMINIA CITY. EKB Journal Management System, 2017; 17(2): 13-25. doi: 10.21608/ejfsat.2017.46118

ROLE OF ß2 MICRO-GLOBULIN IN EARLY ASSESSMENT OF RENAL AFFECTION IN LEAD BATTERY WORKERSMINIA CITY

The Egyptian Journal of Forensic Sciences and Applied Toxicology
Article 2, Volume 17, Issue 2, December 2017, Page 13-25  XML PDF (1.09 MB)
Document Type: Original Article
DOI: 10.21608/ejfsat.2017.46118
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Authors
Asmaa Mohamed Mahmoud1; Jaklin Fekri Zaher1; Mohamed Ismail Hafez2; Eman Ismail Hasan2; Alia Mohamed Mounir3
1Forensic Medicine & clinical Toxicology Department,Faculty of Medicine - Minia University
2Forensic Medicine & clinical Toxicology Department, Faculty of Medicine - Minia University
3Clinical Pathology Department, Faculty of Medicine - Minia University
Abstract
Environmental pollution by lead is a major concern for public health. The aim of this study was to determine renal parameters which are suitable for early assessment of renal affection in lead battery workers. Subjects & Methodology: Sixty subjects (all males) were included in this study, ten volunteer subjects as control (group I) and fifty workers categorized as study subjects who worked on lead battery factories in Minia city-Minia Governorate .The workers included in this study were divided into two group according to their blood lead level (BLL), (group II): included twenty-four workers with blood lead level < 20 µg/dl and (group III): included twenty-six workers with blood lead ≥ 20 µg/dl. Laboratory investigations were done for all subjects of the study including BLL, urinary delta-Aminolevulinic acid (δ –ALA), renal function indices as blood urea, serum creatinine, serum uric acid, and serum ß2 microglobulin. Results: Group II parameters were within normal except ß2 microglobulin which was higher than its normal value. Workers in group III were found to have significantly higher levels of, blood urea, serum creatinine, serum uric acid, ß2 microglobulin and urinary δ –ALA than workers in group II and control group. Although there was significant positive correlation between BLL and all studied parameters, ß2 microglobulin had the highest positivity followed by serum uric acid. Conclusion: increase in BLL causes positive renal effects. ß2 microglobulin followed by serum uric acid is good early predictor for renal affection in lead exposed workers
Keywords
Lead battery workers; renal function; ß2 microglobulin
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