Medicolegal Study of Serum C-Reactive Protein and Troponin I in victims with Head Injury
El-Sarnagawy, G., Fathy, A., Elatrozy, H., Abou Elgheit, H., Elbelkasy, A., Fathy, A. (2018). Medicolegal Study of Serum C-Reactive Protein and Troponin I in victims with Head Injury. EKB Journal Management System, 26(1), 23-38. doi: 10.21608/mjfmct.2018.46381
Ghada N El-Sarnagawy; Amal S Fathy; Hytham I Elatrozy; Hussein M Abou Elgheit; Ahmed M Elbelkasy; Ahmed G Fathy. "Medicolegal Study of Serum C-Reactive Protein and Troponin I in victims with Head Injury". EKB Journal Management System, 26, 1, 2018, 23-38. doi: 10.21608/mjfmct.2018.46381
El-Sarnagawy, G., Fathy, A., Elatrozy, H., Abou Elgheit, H., Elbelkasy, A., Fathy, A. (2018). 'Medicolegal Study of Serum C-Reactive Protein and Troponin I in victims with Head Injury', EKB Journal Management System, 26(1), pp. 23-38. doi: 10.21608/mjfmct.2018.46381
El-Sarnagawy, G., Fathy, A., Elatrozy, H., Abou Elgheit, H., Elbelkasy, A., Fathy, A. Medicolegal Study of Serum C-Reactive Protein and Troponin I in victims with Head Injury. EKB Journal Management System, 2018; 26(1): 23-38. doi: 10.21608/mjfmct.2018.46381

Medicolegal Study of Serum C-Reactive Protein and Troponin I in victims with Head Injury

Mansoura Journal of Forensic Medicine and Clinical Toxicology
Article 3, Volume 26, Issue 1, January 2018, Page 23-38  XML PDF (526.14 K)
Document Type: Original Article
DOI: 10.21608/mjfmct.2018.46381
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Authors
Ghada N El-Sarnagawy email 1; Amal S Fathy1; Hytham I Elatrozy2; Hussein M Abou Elgheit2; Ahmed M Elbelkasy3; Ahmed G Fathy3
1Forensic Medicine and Clinical Toxicology Department. Tanta Faculty of Medicine, Tanta University, Egypt.
2Neurosurgery Department. Tanta Faculty of Medicine, Tanta University, Egypt
3Neurosurgery Department. Tanta Faculty of Medicine, Tanta University, Egypt.
Abstract
Traumatic head injury is a major concern to neurosurgeons and forensic experts. The aim of this study was firstly to determine the pattern of traumatic head injuries and its contributing factors, and secondly to investigate the clinical and forensic importance of serum C- reactive protein (CRP) and cardiac troponin I (cTnI) as promising diagnostic and prognostic biomarkers in victims with traumatic head injuries. Sixty head injured victims were categorized according to Glasgow coma scale into two groups: mild (13-15) and moderate-severe (3-12). Levels of CRP and cTnI were measured on admission and 24 hours later. Serum levels of CRP and cTnI were significantly higher in moderate-severe group (than mild group) and showed significant changes after 24 hours. Elevated CRP serum level after 24 hours above 12 mg/L was associated with poor victims’ outcome. Both CRP and cTnI levels - whether on admission or after 24 hours - correlated significantly with hospital stay. In conclusion, serum CRP and cTnI can be used as markers to investigate severity and outcome of head injured victims.
Keywords
Traumatic head injury; Cardiac Troponin I; C- reactive protein; biological markers
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