ESTIMATION OF HOMOCYSTEINE LEVELS IN TYPE 2 NON HYPERTENSIVE AND HYPERTENSIVE DIABETIC PATIENTS
El-Maghraby, A., Aissa, E., Ibrahim, L. (2016). ESTIMATION OF HOMOCYSTEINE LEVELS IN TYPE 2 NON HYPERTENSIVE AND HYPERTENSIVE DIABETIC PATIENTS. EKB Journal Management System, 22(3), 1-8. doi: 10.21608/zumj.2016.4644
Amal El-Maghraby; Eman Aissa; Lobna Ibrahim. "ESTIMATION OF HOMOCYSTEINE LEVELS IN TYPE 2 NON HYPERTENSIVE AND HYPERTENSIVE DIABETIC PATIENTS". EKB Journal Management System, 22, 3, 2016, 1-8. doi: 10.21608/zumj.2016.4644
El-Maghraby, A., Aissa, E., Ibrahim, L. (2016). 'ESTIMATION OF HOMOCYSTEINE LEVELS IN TYPE 2 NON HYPERTENSIVE AND HYPERTENSIVE DIABETIC PATIENTS', EKB Journal Management System, 22(3), pp. 1-8. doi: 10.21608/zumj.2016.4644
El-Maghraby, A., Aissa, E., Ibrahim, L. ESTIMATION OF HOMOCYSTEINE LEVELS IN TYPE 2 NON HYPERTENSIVE AND HYPERTENSIVE DIABETIC PATIENTS. EKB Journal Management System, 2016; 22(3): 1-8. doi: 10.21608/zumj.2016.4644

ESTIMATION OF HOMOCYSTEINE LEVELS IN TYPE 2 NON HYPERTENSIVE AND HYPERTENSIVE DIABETIC PATIENTS

Zagazig University Medical Journal
Article 2, Volume 22, Issue 3, May 2016, Page 1-8  XML PDF (599.66 K)
Document Type: Original Article
DOI: 10.21608/zumj.2016.4644
View on SCiNiTO View on SCiNiTO
Authors
Amal El-Maghraby1; Eman Aissa2; Lobna Ibrahim3
1Departments of General Medicine , Benha Teaching Hospital;Benha, Egypt
2Departments of Clinical Pathology, Benha Teaching Hospital;Benha, Egypt
3Clinical Pathology, Benha Teaching Hospital;Benha, Egypt
Abstract
Background: Hyperhomocysteinemia increases risk of morbidity and mortality secondary to cardiovascular diseases such as increased risk of atherosclerosis, ischemic heart disease and peripheral vascular disease and has been associated with microalbuminuria in type II diabetes mellitus. Subjects and Methods: 100 patients, 50 hypertensive diabetic patients, 50 normotensive diabetic patients, and 20 patients as control group matched for age, gender and body mass index (BMI) and were clinically assessed and laboratory investigations were done through estimation of plasma homocysteine, lipid profile, fasting and two hours post prandial blood glucose, and serum creatinine. Results: Homocysteine was elevated more in hypertensive diabetic group than diabetic group with high significant correlation (P=0.001), moreover homocysteine was highly significant correlated to BMI fasting blood glucose, cholesterol, serum triglyceride (P=0.001), and insignificant correlation to serum creatinine in both goups. Conclusion: Homocysteine is a significant risk factor in hypertensive diabetic patients. Using folic acid supplement 0.4mg daily is essential to reduce level of serum homocysteine especially in hypertensive, diabetic patients to decrease risk of cardiovascular events in addition of controling blood pressure, blood sugar and obesity.
Keywords
Homocysteine; Hypertension; Type II DM; Cardiovascular disease
Statistics
Article View: 219
PDF Download: 610