CHOLESTASIS: MOLECULAR MECHANISM, PATHOGENESIS AND POSSIBLE MANAGEMENT | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 6, Volume 58, Issue 2, September and October 2018, Page 93-114 PDF (674.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2018.46644 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Basant Al-Botaty | ||||
| Pharmacology and Toxicology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt | ||||
| Abstract | ||||
| Understanding the molecular mechanism of bile formation and the different pathways and pathogenesis of drug induced cholestasis provide different possibilities for treatment. This review summarizes the role of transport proteins in hepatic drug clearance and toxicity, the involvement of inflammatory mediators in cholestasis and the role of nuclear receptors in bile acid metabolism. Understanding nuclear receptor function can help in the development of nuclear receptor ligands for treatment of cholestasis. | ||||
| Keywords | ||||
| Bile acids; nuclear receptors; Inflammatory mediators; Management | ||||
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