ASSOCIATION BETWEEN TRANSFORMING GROWTH FACTOR-β1 AND INTERLEUKIN-4 AND CHILDHOOD ASTHMA IN ZAGAZIG UNIVERSITY HOSPITALS | ||||
| Zagazig University Medical Journal | ||||
| Article 5, Volume 22, Issue 5, September 2016, Page 1-6 PDF (654.25 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2016.4669 | ||||
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| Authors | ||||
| Mohamed Naguib1; Mohamed Abd-Elsalam2; Amal Abd El-Azeem3; Yousif Yousif4 | ||||
| 1Professor of Pediatrics, faculty of medicine, Zagazig University, Egypt. | ||||
| 2Ass. Prof. of Pediatrics, faculty of medicine, Zagazig University, Egypt | ||||
| 3Ass. Prof. of Medical Biochemistry, faculty of medicine, Zagazig University, Egypt. | ||||
| 4Ass. lecturer of Pediatrics, faculty of medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Interleukin (IL) 4 and transforming growth factor β1 (TGF-β1) are two key cytokines involved in a Th2-type inflammation characteristic of asthma. This type has more inflammatory cells that release cytokines which trigger broncho-constriction, mucus over-production, and remodeling of airways which augment inflammatory reactions in asthma. Objective: Our study aimed to verify the association of serum levels of both IL 4 and TGF-β1 with asthma development and further effect on its control level in Egyptian children. Subjects and methods: In this case-control study, two groups of children aged 5–15 years were recruited: first diagnosed as cases of asthma (clinically and spirometry-based); the second group of non-asthmatic children was enrolled as controls. Serum levels of total IgE, IL 4 and TGF-β1 were measured for all children. Cases were classified as controlled, partly controlled and uncontrolled (according to GINA 2008) Results: From December 2013 to Mai 2015, 156 cases and 156 controls were recruited. Serum level of serum total IgE, TGF-β1 and IL4 were significantly higher in asthmatic in comparison to non-asthmatic children. A positive correlation between serum levels of both total IgE and IL-4 and TGF-β1were noted. A higher serum level of total IgE, TGF-β1 and IL4 were noticed in children with poor asthma control. Conclusion: The data suggests that increased serum levels both TGF-β1 and IL4 in asthmatic children are associated with poor asthma control. | ||||
| Keywords | ||||
| Asthma; IL4; TGF-β1 | ||||
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